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6. Ligases

6.2 Forming carbon-sulfur bonds

6.2.1 Acid-thiol ligases

ID:	6.2.1.52
Description:	L-firefly luciferin--CoA ligase.

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UniProtKB Enzyme Link:	UniProtKB 6.2.1.52
BRENDA Enzyme Link:	BRENDA 6.2.1.52
KEGG Enzyme Link:	KEGG6.2.1.52
BioCyc Enzyme Link:	BioCyc 6.2.1.52
ExPASy Enzyme Link:	ExPASy6.2.1.52
EC2PDB Enzyme Link:	EC2PDB 6.2.1.52
ExplorEnz Enzyme Link:	ExplorEnz 6.2.1.52
PRIAM enzyme-specific profiles Link:	PRIAM 6.2.1.52
IntEnz Enzyme Link:	IntEnz 6.2.1.52
MEDLINE Enzyme Link:	MEDLINE 6.2.1.52

RHEA:54748	ATP + CoA + L-firefly luciferin = AMP + diphosphate + L-firefly luciferyl-CoA
RULE(radius=1)	[:1]-[P;H0;+0:2](=[:3])(-[:4])-[O;H0;+0:5]-[:6].[:7]-[SH;+0:8].[:9]=[C;H0;+0:10](-[:11])-[OH;+0:12]>>[:6]-[OH;+0:5].[:1]-[P;H0;+0:2](=[:3])(-[:4])-[OH;+0:12].[:7]-[S;H0;+0:8]-[C;H0;+0:10](=[:9])-[:11]
Reaction
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Title	Authors	Date	PubMed ID
Biosynthesis-inspired deracemizative production of d-luciferin by combining luciferase and thioesterase.	Maeda J, Kato DI, Okuda M, Takeo M, Negoro S, Arima K, Ito Y, Niwa K	2017 Aug	28454735
The origin of luciferase activity in Zophobas mealworm AMP/CoA-ligase (protoluciferase): luciferin stereoselectivity as a switch for the oxygenase activity.	Viviani VR, Scorsato V, Prado RA, Pereira JG, Niwa K, Ohmiya Y, Barbosa JA	2010 Aug	20526507
Firefly luciferase exhibits bimodal action depending on the luciferin chirality.	Nakamura M, Maki S, Amano Y, Ohkita Y, Niwa K, Hirano T, Ohmiya Y, Niwa H	2005 Jun 3	15850783
Identification of luciferyl adenylate and luciferyl coenzyme a synthesized by firefly luciferase.	Fraga H, Esteves da Silva JC, Fontes R	2004 Jan 3	14695520