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6. Ligases

6.2 Forming carbon-sulfur bonds

6.2.1 Acid-thiol ligases

ID:	6.2.1.53
Description:	L-proline--[L-prolyl-carrier protein] ligase.

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UniProtKB Enzyme Link:	UniProtKB 6.2.1.53
BRENDA Enzyme Link:	BRENDA 6.2.1.53
KEGG Enzyme Link:	KEGG6.2.1.53
BioCyc Enzyme Link:	BioCyc 6.2.1.53
ExPASy Enzyme Link:	ExPASy6.2.1.53
EC2PDB Enzyme Link:	EC2PDB 6.2.1.53
ExplorEnz Enzyme Link:	ExplorEnz 6.2.1.53
PRIAM enzyme-specific profiles Link:	PRIAM 6.2.1.53
IntEnz Enzyme Link:	IntEnz 6.2.1.53
MEDLINE Enzyme Link:	MEDLINE 6.2.1.53

RHEA:11656	ATP + holo-[peptidyl-carrier protein] + L-proline = AMP + diphosphate + L-prolyl-[peptidyl-carrier protein]
RULE(radius=1)	[:1]-[O;H0;+0:2]-[P;H0;+0:3](-[:4])(=[:5])-[:6].[:7]-[SH;+0:8].[:9]=[C;H0;+0:10](-[:11])-[OH;+0:12]>>[:1]-[OH;+0:2].[:4]-[P;H0;+0:3](=[:5])(-[:6])-[OH;+0:12].[:7]-[S;H0;+0:8]-[C;H0;+0:10](=[:9])-[:11]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
The Serratia gene cluster encoding biosynthesis of the red antibiotic, prodigiosin, shows species- and strain-dependent genome context variation.	Harris AK, Williamson NR, Slater H, Cox A, Abbasi S, Foulds I, Simonsen HT, Leeper FJ, Salmond GP	2004 Nov	15528645
Conversion of L-proline to pyrrolyl-2-carboxyl-S-PCP during undecylprodigiosin and pyoluteorin biosynthesis.	Thomas MG, Burkart MD, Walsh CT	2002 Feb	11880032
Biosynthesis of the red antibiotic, prodigiosin, in Serratia: identification of a novel 2-methyl-3-n-amyl-pyrrole (MAP) assembly pathway, definition of the terminal condensing enzyme, and implications for undecylprodigiosin biosynthesis in Streptomyces.	Williamson NR, Simonsen HT, Ahmed RA, Goldet G, Slater H, Woodley L, Leeper FJ, Salmond GP	2005 May	15853884