EC number:6.2.1.7
| ID: | 6.2.1.7 |
|---|---|
| Description: | Cholate--CoA ligase. |
| Alternative Name: |
Trihydroxycoprostanoyl-CoA synthetase. THCA-CoA ligase. Cholyl-CoA synthetase. Choloyl-CoA synthetase. Choloyl coenzyme A synthetase. Cholic thiokinase. Cholic acid:CoA ligase. Cholate thiokinase. Bile acid coenzyme A ligase. Bile acid CoA ligase. BAL. synthetase. 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl coenzyme A 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA synthetase. 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA ligase. forming). 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate:CoA ligase (AMP- 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate--CoA ligase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 6.2.1.7 |
| BRENDA Enzyme Link: | BRENDA 6.2.1.7 |
| KEGG Enzyme Link: | KEGG6.2.1.7 |
| BioCyc Enzyme Link: | BioCyc 6.2.1.7 |
| ExPASy Enzyme Link: | ExPASy6.2.1.7 |
| EC2PDB Enzyme Link: | EC2PDB 6.2.1.7 |
| ExplorEnz Enzyme Link: | ExplorEnz 6.2.1.7 |
| PRIAM enzyme-specific profiles Link: | PRIAM 6.2.1.7 |
| IntEnz Enzyme Link: | IntEnz 6.2.1.7 |
| MEDLINE Enzyme Link: | MEDLINE 6.2.1.7 |
| RHEA:23532 | ATP + cholate + CoA = AMP + choloyl-CoA + diphosphate |
| RULE(radius=1) | [*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[*:7]-[SH;+0:8].[*:9]=[C;H0;+0:10](-[*:11])-[OH;+0:12]>>[*:6]-[OH;+0:5].[*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[OH;+0:12].[*:7]-[S;H0;+0:8]-[C;H0;+0:10](=[*:9])-[*:11] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Molecular cloning and expression of rat liver bile acid CoA ligase. | Falany CN, Xie X, Wheeler JB, Wang J, Smith M, He D, Barnes S | 2002 Dec | 12454267 |
| Determination of the mechanism of reaction for bile acid: CoA ligase. | Kelley M, Vessey DA | 1994 Dec 15 | 7818501 |
| Actinobacterial acyl coenzyme A synthetases involved in steroid side-chain catabolism. | Casabon I, Swain K, Crowe AM, Eltis LD, Mohn WW | 2014 Feb | 24244004 |
| The bile acid-inducible baiB gene from Eubacterium sp. strain VPI 12708 encodes a bile acid-coenzyme A ligase. | Mallonee DH, Adams JL, Hylemon PB | 1992 Apr | 1551828 |
| Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling. | Mihalik SJ, Steinberg SJ, Pei Z, Park J, Kim DG, Heinzer AK, Dacremont G, Wanders RJ, Cuebas DA, Smith KD, Watkins PA | 2002 Jul 5 | 11980911 |
| RHEA:22976 | (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate |
| RULE(radius=1) | [*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[*:7]-[SH;+0:8].[*:9]=[C;H0;+0:10](-[*:11])-[OH;+0:12]>>[*:6]-[OH;+0:5].[*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[OH;+0:12].[*:9]=[C;H0;+0:10](-[*:11])-[S;H0;+0:8]-[*:7] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Molecular cloning and expression of rat liver bile acid CoA ligase. | Falany CN, Xie X, Wheeler JB, Wang J, Smith M, He D, Barnes S | 2002 Dec | 12454267 |
| Determination of the mechanism of reaction for bile acid: CoA ligase. | Kelley M, Vessey DA | 1994 Dec 15 | 7818501 |
| Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling. | Mihalik SJ, Steinberg SJ, Pei Z, Park J, Kim DG, Heinzer AK, Dacremont G, Wanders RJ, Cuebas DA, Smith KD, Watkins PA | 2002 Jul 5 | 11980911 |