EC number:6.3.1.13
Enzyme
Download| EC Tree |
| 6. Ligases |
| 6.3 Forming carbon-nitrogen bonds |
| 6.3.1 Acid-D-ammonia (or amine) ligases (amide synthases) |
| ID: | 6.3.1.13 |
|---|---|
| Description: | ligase. |
| Alternative Name: |
Mycothiol ligase. MshC ligase. |
| Cath: | 1.20.120.640; 3.40.50.620; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 6.3.1.13 |
| BRENDA Enzyme Link: | BRENDA 6.3.1.13 |
| KEGG Enzyme Link: | KEGG6.3.1.13 |
| BioCyc Enzyme Link: | BioCyc 6.3.1.13 |
| ExPASy Enzyme Link: | ExPASy6.3.1.13 |
| EC2PDB Enzyme Link: | EC2PDB 6.3.1.13 |
| ExplorEnz Enzyme Link: | ExplorEnz 6.3.1.13 |
| PRIAM enzyme-specific profiles Link: | PRIAM 6.3.1.13 |
| IntEnz Enzyme Link: | IntEnz 6.3.1.13 |
| MEDLINE Enzyme Link: | MEDLINE 6.3.1.13 |
| RHEA:26176 | 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + ATP + L-cysteine = 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+) |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]-[O;H0;+0:4]-[P;H0;+0:5](-[*:6])(=[*:7])-[*:8].[*:9]=[C;H0;+0:10](-[*:11])-[OH;+0:12]>>[*:1]-[NH;+0:2]-[C;H0;+0:10](=[*:9])-[*:11].[*:3]-[OH;+0:4].[*:6]-[P;H0;+0:5](=[*:7])(-[*:8])-[OH;+0:12] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The 1.6 A crystal structure of Mycobacterium smegmatis MshC: the penultimate enzyme in the mycothiol biosynthetic pathway. | Tremblay LW, Fan F, Vetting MW, Blanchard JS | 2008 Dec 16 | 19053270 |
| Steady-state and pre-steady-state kinetic analysis of Mycobacterium smegmatis cysteine ligase (MshC). | Fan F, Luxenburger A, Painter GF, Blanchard JS | 2007 Oct 9 | 17848100 |
| ATP-dependent L-cysteine:1D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, mycothiol biosynthesis enzyme MshC, is related to class I cysteinyl-tRNA synthetases. | Sareen D, Steffek M, Newton GL, Fahey RC | 2002 Jun 4 | 12033919 |