EC number:6.3.1.14

Enzyme

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     6. Ligases
        6.3 Forming carbon-nitrogen bonds
            6.3.1 Acid-D-ammonia (or amine) ligases (amide synthases)
ID:6.3.1.14
Description:Diphthine--ammonia ligase.
Alternative Name: Diphthamide synthetase.
Diphthamide synthase.
Cath: 3.30.950.10; 3.40.1010.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.3.1.14
BRENDA Enzyme Link: BRENDA 6.3.1.14
KEGG Enzyme Link: KEGG6.3.1.14
BioCyc Enzyme Link: BioCyc 6.3.1.14
ExPASy Enzyme Link: ExPASy6.3.1.14
EC2PDB Enzyme Link: EC2PDB 6.3.1.14
ExplorEnz Enzyme Link: ExplorEnz 6.3.1.14
PRIAM enzyme-specific profiles Link: PRIAM 6.3.1.14
IntEnz Enzyme Link: IntEnz 6.3.1.14
MEDLINE Enzyme Link: MEDLINE 6.3.1.14

EC number:6.3.1.14

MSA:

6.3.1.14;
Phylogenetic Tree:

6.3.1.14;
Uniprot:
M-CSA:
RHEA:19753 ATP + diphthine-[translation elongation factor 2] + NH4(+) = AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+)
RULE(radius=1) [*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:4].[*:5]-[O;H0;+0:6]-[P;H0;+0:7](-[*:8])(=[*:9])-[*:10].[NH3;+0:11]>>[*:1]-[C;H0;+0:2](=[*:3])-[NH2;+0:11].[*:5]-[OH;+0:6].[*:8]-[P;H0;+0:7](=[*:9])(-[*:10])-[OH;+0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
The post-translational trimethylation of diphthamide studied in vitro.Moehring JM, Moehring TJ1988 Mar 153346227
Chemogenomic approach identified yeast YLR143W as diphthamide synthetase.Su X, Lin Z, Chen W, Jiang H, Zhang S, Lin H2012 Dec 423169644