EC number:6.3.1.2

Enzyme

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EC Tree
     6. Ligases
        6.3 Forming carbon-nitrogen bonds
            6.3.1 Acid-D-ammonia (or amine) ligases (amide synthases)
ID:6.3.1.2
Description:Glutamine synthetase.
Alternative Name: L-glutamine synthetase.
Glutamate--ammonia ligase.
Prosite: PDOC00162;
PDB:
PDBScop
1HTQ 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671;
1HTO 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671;
2WGS 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671;
4ACF 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671;
3ZXV 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671; 8026290; 8026292; 8038669; 8038671;
 » show all
Cath: 1.10.4050.10; 1.20.120.1510; 1.20.120.1560; 1.20.120.330; 3.30.460.10; 3.30.460.100; 3.30.590.10; 3.30.590.40; 3.40.630.30; 3.10.20.70;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.3.1.2
BRENDA Enzyme Link: BRENDA 6.3.1.2
KEGG Enzyme Link: KEGG6.3.1.2
BioCyc Enzyme Link: BioCyc 6.3.1.2
ExPASy Enzyme Link: ExPASy6.3.1.2
EC2PDB Enzyme Link: EC2PDB 6.3.1.2
ExplorEnz Enzyme Link: ExplorEnz 6.3.1.2
PRIAM enzyme-specific profiles Link: PRIAM 6.3.1.2
IntEnz Enzyme Link: IntEnz 6.3.1.2
MEDLINE Enzyme Link: MEDLINE 6.3.1.2

EC number:6.3.1.2

MSA:

6.3.1.2;
Phylogenetic Tree:

6.3.1.2;
Uniprot:
M-CSA:
RHEA:16169 ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate
RULE(radius=1) [*:1]=[C;H0;+0:2](-[*:3])-[OH;+0:4].[*:5]=[P;H0;+0:6](-[*:7])(-[*:8])-[O;H0;+0:9]-[*:10].[NH3;+0:11]>>[*:10]-[OH;+0:9].[*:1]=[C;H0;+0:2](-[*:3])-[NH2;+0:11].[*:5]=[P;H0;+0:6](-[*:7])(-[*:8])-[OH;+0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction