EC number:6.3.2.10

Enzyme

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     6. Ligases
        6.3 Forming carbon-nitrogen bonds
            6.3.2 Acid-D-amino-acid ligases (peptide synthases)
ID:6.3.2.10
Description:UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase.
Alternative Name: Uridine diphosphoacetylmuramoylpentapeptide synthetase.
UDPacetylmuramoylpentapeptide synthetase.
UDP-N-acetylmuramoylalanyl-D-glutamyl-lysine-D-alanyl-D-alanine ligase.
alanine ligase.
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-
UDP-N-acetylmuramoylalanine-D-glutamyl-lysine--D-alanyl-D-alanine ligase.
alanyl-D-alanine synthetase.
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-
synthetase.
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine
UDP-MurNAc-pentapeptide synthetase.
UDP-MurNAc-L-Ala-D-Glu-L-Lys:D-Ala-D-Ala ligase.
MurF synthetase.
Cath: 3.30.1490.20; 3.30.470.20; 3.40.1190.10; 3.40.1390.10; 3.90.190.20; 3.40.50.20;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.3.2.10
BRENDA Enzyme Link: BRENDA 6.3.2.10
KEGG Enzyme Link: KEGG6.3.2.10
BioCyc Enzyme Link: BioCyc 6.3.2.10
ExPASy Enzyme Link: ExPASy6.3.2.10
EC2PDB Enzyme Link: EC2PDB 6.3.2.10
ExplorEnz Enzyme Link: ExplorEnz 6.3.2.10
PRIAM enzyme-specific profiles Link: PRIAM 6.3.2.10
IntEnz Enzyme Link: IntEnz 6.3.2.10
MEDLINE Enzyme Link: MEDLINE 6.3.2.10

EC number:6.3.2.10

MSA:

6.3.2.10;
Phylogenetic Tree:

6.3.2.10;
Uniprot:
M-CSA:
RHEA:16085 ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine
RULE(radius=1) [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[OH;+0:6].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[O;H0;+0:11]-[*:12]>>[*:1]-[NH;+0:2]-[C;H0;+0:4](=[*:3])-[*:5].[*:12]-[OH;+0:11].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[OH;+0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Recent advances in the formation of the bacterial peptidoglycan monomer unit.van Heijenoort J2001 Oct11699883