EC number:6.3.2.11

Enzyme

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     6. Ligases
        6.3 Forming carbon-nitrogen bonds
            6.3.2 Acid-D-amino-acid ligases (peptide synthases)
ID:6.3.2.11
Description:Carnosine synthase.
Alternative Name: Carnosine synthetase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.3.2.11
BRENDA Enzyme Link: BRENDA 6.3.2.11
KEGG Enzyme Link: KEGG6.3.2.11
BioCyc Enzyme Link: BioCyc 6.3.2.11
ExPASy Enzyme Link: ExPASy6.3.2.11
EC2PDB Enzyme Link: EC2PDB 6.3.2.11
ExplorEnz Enzyme Link: ExplorEnz 6.3.2.11
PRIAM enzyme-specific profiles Link: PRIAM 6.3.2.11
IntEnz Enzyme Link: IntEnz 6.3.2.11
MEDLINE Enzyme Link: MEDLINE 6.3.2.11

EC number:6.3.2.11

MSA:

6.3.2.11;
Phylogenetic Tree:

6.3.2.11;
Uniprot:
M-CSA:
RHEA:19297 ATP + beta-alanine + L-histidine = ADP + carnosine + H(+) + phosphate
RULE(radius=1) [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[OH;+0:6].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[O;H0;+0:11]-[*:12]>>[*:1]-[NH;+0:2]-[C;H0;+0:4](=[*:3])-[*:5].[*:12]-[OH;+0:11].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[OH;+0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Biosynthesis of Carnosine and Related Dipeptides in Vertebrates.Kwiatkowski S, Kiersztan A, Drozak J201829484990
Molecular identification of carnosine synthase as ATP-grasp domain-containing protein 1 (ATPGD1).Drozak J, Veiga-da-Cunha M, Vertommen D, Stroobant V, Van Schaftingen E2010 Mar 2620097752