EC number:6.3.2.12
Enzyme
Download| EC Tree |
| 6. Ligases |
| 6.3 Forming carbon-nitrogen bonds |
| 6.3.2 Acid-D-amino-acid ligases (peptide synthases) |
| ID: | 6.3.2.12 |
|---|---|
| Description: | Dihydrofolate synthase. |
| Alternative Name: |
H(2)-folate synthetase. Dihydrofolate synthetase. DHFS. 7,8-dihydrofolate synthetase. |
| Cath: | 3.40.1190.10; 3.90.190.20; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 6.3.2.12 |
| BRENDA Enzyme Link: | BRENDA 6.3.2.12 |
| KEGG Enzyme Link: | KEGG6.3.2.12 |
| BioCyc Enzyme Link: | BioCyc 6.3.2.12 |
| ExPASy Enzyme Link: | ExPASy6.3.2.12 |
| EC2PDB Enzyme Link: | EC2PDB 6.3.2.12 |
| ExplorEnz Enzyme Link: | ExplorEnz 6.3.2.12 |
| PRIAM enzyme-specific profiles Link: | PRIAM 6.3.2.12 |
| IntEnz Enzyme Link: | IntEnz 6.3.2.12 |
| MEDLINE Enzyme Link: | MEDLINE 6.3.2.12 |
| RHEA:23584 | 7,8-dihydropteroate + ATP + L-glutamate = 7,8-dihydrofolate + ADP + H(+) + phosphate |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[OH;+0:6].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[O;H0;+0:11]-[*:12]>>[*:12]-[OH;+0:11].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Folates and one-carbon metabolism in plants and fungi. | Cossins EA, Chen L | 1997 Jun | 9190084 |
| Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase. Cloning and high expression of the Escherichia coli folC gene and purification and properties of the gene product. | Bognar AL, Osborne C, Shane B, Singer SC, Ferone R | 1985 May 10 | 2985605 |
| THE BIOSYNTHESIS OF FOLIC ACID. III. ENZYMATIC FORMATION OF DIHYDROFOLIC ACID FROM DIHYDROPTEROIC ACID AND OF TETRAHYDROPTEROYLPOLYGLUTAMIC ACID COMPOUNDS FROM TETRAHYDROFOLIC ACID. | GRIFFIN MJ, BROWN GM | 1964 Jan | 14114858 |
| Tetrahydrofolate biosynthesis in plants: molecular and functional characterization of dihydrofolate synthetase and three isoforms of folylpolyglutamate synthetase in Arabidopsis thaliana. | Ravanel S, Cherest H, Jabrin S, Grunwald D, Surdin-Kerjan Y, Douce R, Rébeillé F | 2001 Dec 18 | 11752472 |
| Polyglutamylation of folate coenzymes is necessary for methionine biosynthesis and maintenance of intact mitochondrial genome in Saccharomyces cerevisiae. | Cherest H, Thomas D, Surdin-Kerjan Y | 2000 May 12 | 10799479 |