EC number:6.3.2.13
Enzyme
Download| EC Tree |
| 6. Ligases |
| 6.3 Forming carbon-nitrogen bonds |
| 6.3.2 Acid-D-amino-acid ligases (peptide synthases) |
| ID: | 6.3.2.13 |
|---|---|
| Description: | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. |
| Alternative Name: |
UDP-N-acetylmuramyl-tripeptide synthetase. UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase. synthetase. UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate ligase (ADP-forming). UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diamino-heptanedioate MurE synthetase. |
| Cath: | 3.30.1490.20; 3.30.470.20; 3.40.1190.10; 3.40.1390.10; 3.90.190.20; 3.40.50.20; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 6.3.2.13 |
| BRENDA Enzyme Link: | BRENDA 6.3.2.13 |
| KEGG Enzyme Link: | KEGG6.3.2.13 |
| BioCyc Enzyme Link: | BioCyc 6.3.2.13 |
| ExPASy Enzyme Link: | ExPASy6.3.2.13 |
| EC2PDB Enzyme Link: | EC2PDB 6.3.2.13 |
| ExplorEnz Enzyme Link: | ExplorEnz 6.3.2.13 |
| PRIAM enzyme-specific profiles Link: | PRIAM 6.3.2.13 |
| IntEnz Enzyme Link: | IntEnz 6.3.2.13 |
| MEDLINE Enzyme Link: | MEDLINE 6.3.2.13 |
| RHEA:23676 | ATP + meso-2,6-diaminopimelate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminopimelate |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[OH;+0:6].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[O;H0;+0:11]-[*:12]>>[*:12]-[OH;+0:11].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Recent advances in the formation of the bacterial peptidoglycan monomer unit. | van Heijenoort J | 2001 Oct | 11699883 |
| Purification and properties of uridine diphosphate N-acetylmuramyl-L-alanyl-D-glutamate:meso-2,6-diaminopimelate ligase. | Mizuno Y, Ito E | 1968 May 25 | 4967958 |
| Over-production, purification and properties of the uridine-diphosphate-N-acetylmuramoyl-L-alanyl-D-glutamate: meso-2,6-diaminopimelate ligase from Escherichia coli. | Michaud C, Mengin-Lecreulx D, van Heijenoort J, Blanot D | 1990 Dec 27 | 2269304 |
| Comparative modeling of UDP-N-acetylmuramoyl-glycyl-D-glutamate-2, 6-diaminopimelate ligase from Mycobacterium leprae and analysis of its binding features through molecular docking studies. | Shanmugam A, Natarajan J | 2012 Jan | 21491188 |
| Crystal structure of UDP-N-acetylmuramoyl-L-alanyl-D-glutamate: meso-diaminopimelate ligase from Escherichia coli. | Gordon E, Flouret B, Chantalat L, van Heijenoort J, Mengin-Lecreulx D, Dideberg O | 2001 Apr 6 | 11124264 |