EC number:6.3.2.2

Enzyme

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EC Tree
     6. Ligases
        6.3 Forming carbon-nitrogen bonds
            6.3.2 Acid-D-amino-acid ligases (peptide synthases)
ID:6.3.2.2
Description:Glutamate--cysteine ligase.
Alternative Name: Gamma-glutamylcysteine synthetase.
Gamma-glutamyl-L-cysteine synthetase.
Cath: 1.10.150.710; 1.10.287.2270; 1.10.8.960; 3.30.590.20; 3.30.590.50;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.3.2.2
BRENDA Enzyme Link: BRENDA 6.3.2.2
KEGG Enzyme Link: KEGG6.3.2.2
BioCyc Enzyme Link: BioCyc 6.3.2.2
ExPASy Enzyme Link: ExPASy6.3.2.2
EC2PDB Enzyme Link: EC2PDB 6.3.2.2
ExplorEnz Enzyme Link: ExplorEnz 6.3.2.2
PRIAM enzyme-specific profiles Link: PRIAM 6.3.2.2
IntEnz Enzyme Link: IntEnz 6.3.2.2
MEDLINE Enzyme Link: MEDLINE 6.3.2.2

EC number:6.3.2.2

MSA:

6.3.2.2;
Phylogenetic Tree:

6.3.2.2;
Uniprot:
M-CSA:
RHEA:13285 ATP + L-cysteine + L-glutamate = ADP + H(+) + L-gamma-glutamyl-L-cysteine + phosphate
RULE(radius=1) [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[OH;+0:6].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[O;H0;+0:11]-[*:12]>>[*:12]-[OH;+0:11].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[OH;+0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction