EC number:6.3.2.25
Enzyme
Download| EC Tree |
| 6. Ligases |
| 6.3 Forming carbon-nitrogen bonds |
| 6.3.2 Acid-D-amino-acid ligases (peptide synthases) |
| ID: | 6.3.2.25 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description: | Tubulin--tyrosine ligase. | ||||||||
| Alternative Name: |
TTL. | ||||||||
| Prosite: | PDOC51221; | ||||||||
| PDB: |
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| Cath: | 3.30.1490.20; 3.30.470.20; 3.40.50.11480; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 6.3.2.25 |
| BRENDA Enzyme Link: | BRENDA 6.3.2.25 |
| KEGG Enzyme Link: | KEGG6.3.2.25 |
| BioCyc Enzyme Link: | BioCyc 6.3.2.25 |
| ExPASy Enzyme Link: | ExPASy6.3.2.25 |
| EC2PDB Enzyme Link: | EC2PDB 6.3.2.25 |
| ExplorEnz Enzyme Link: | ExplorEnz 6.3.2.25 |
| PRIAM enzyme-specific profiles Link: | PRIAM 6.3.2.25 |
| IntEnz Enzyme Link: | IntEnz 6.3.2.25 |
| MEDLINE Enzyme Link: | MEDLINE 6.3.2.25 |
| RHEA:17605 | ATP + C-terminal detyrosinated L-glutamyl-L-glutamyl-[alpha-tubulin] + L-tyrosine = ADP + C-terminal L-tyrosyl-L-glutamyl-L-glutamyl-[alpha-tubulin] + H(+) + phosphate |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:4].[*:5]-[NH2;+0:6].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[O;H0;+0:11]-[*:12]>>[*:5]-[NH;+0:6]-[C;H0;+0:2](-[*:1])=[*:3].[*:12]-[OH;+0:11].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[OH;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Tubulin tyrosine ligase: protein and mRNA expression in developing rat skeletal muscle. | Arregui CO, Mas CR, Argaraña CE, Barra HS | 1997 Apr | 9108330 |
| The carboxy-terminal peptide of detyrosinated alpha tubulin provides a minimal system to study the substrate specificity of tubulin-tyrosine ligase. | Rüdiger M, Wehland J, Weber K | 1994 Mar 1 | 7510228 |
| Isolation and purification of tubulin tyrosine ligase. | Wehland J, Schröder HC, Weber K | 1986 | 3821560 |
| Structural basis of tubulin tyrosination by tubulin tyrosine ligase. | Prota AE, Magiera MM, Kuijpers M, Bargsten K, Frey D, Wieser M, Jaussi R, Hoogenraad CC, Kammerer RA, Janke C, Steinmetz MO | 2013 Feb 4 | 23358242 |
| Tubulin tyrosine ligase structure reveals adaptation of an ancient fold to bind and modify tubulin. | Szyk A, Deaconescu AM, Piszczek G, Roll-Mecak A | 2011 Oct 23 | 22020298 |