EC number:6.3.2.3

Enzyme

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     6. Ligases
        6.3 Forming carbon-nitrogen bonds
            6.3.2 Acid-D-amino-acid ligases (peptide synthases)
ID:6.3.2.3
Description:Glutathione synthase.
Alternative Name: GSH synthetase.
Glutathione synthetase.
Prosite: PDOC50975;
PDB:
PDBScop
Cath: 1.10.1080.10; 3.30.1490.20; 3.30.1490.250; 3.30.1490.50; 3.30.1490.80; 3.30.470.20; 3.30.590.20; 3.40.50.1760; 3.40.50.20;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.3.2.3
BRENDA Enzyme Link: BRENDA 6.3.2.3
KEGG Enzyme Link: KEGG6.3.2.3
BioCyc Enzyme Link: BioCyc 6.3.2.3
ExPASy Enzyme Link: ExPASy6.3.2.3
EC2PDB Enzyme Link: EC2PDB 6.3.2.3
ExplorEnz Enzyme Link: ExplorEnz 6.3.2.3
PRIAM enzyme-specific profiles Link: PRIAM 6.3.2.3
IntEnz Enzyme Link: IntEnz 6.3.2.3
MEDLINE Enzyme Link: MEDLINE 6.3.2.3

EC number:6.3.2.3

MSA:

6.3.2.3;
Phylogenetic Tree:

6.3.2.3;
Uniprot:
M-CSA:
RHEA:13557 ATP + glycine + L-gamma-glutamyl-L-cysteine = ADP + glutathione + H(+) + phosphate
RULE(radius=1) [*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:4].[*:5]-[NH2;+0:6].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[O;H0;+0:11]-[*:12]>>[*:1]-[C;H0;+0:2](=[*:3])-[NH;+0:6]-[*:5].[*:12]-[OH;+0:11].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[OH;+0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
A pseudo-michaelis quaternary complex in the reverse reaction of a ligase: structure of Escherichia coli B glutathione synthetase complexed with ADP, glutathione, and sulfate at 2.0 A resolution.Hara T, Kato H, Katsube Y, Oda J1996 Sep 178810901