EC number:6.3.2.31

Enzyme

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     6. Ligases
        6.3 Forming carbon-nitrogen bonds
            6.3.2 Acid-D-amino-acid ligases (peptide synthases)
ID:6.3.2.31
Description:Coenzyme F420-0:L-glutamate ligase.
Cath: 3.30.1330.10; 3.30.1330.100; 3.40.109.10; 3.90.1660.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.3.2.31
BRENDA Enzyme Link: BRENDA 6.3.2.31
KEGG Enzyme Link: KEGG6.3.2.31
BioCyc Enzyme Link: BioCyc 6.3.2.31
ExPASy Enzyme Link: ExPASy6.3.2.31
EC2PDB Enzyme Link: EC2PDB 6.3.2.31
ExplorEnz Enzyme Link: ExplorEnz 6.3.2.31
PRIAM enzyme-specific profiles Link: PRIAM 6.3.2.31
IntEnz Enzyme Link: IntEnz 6.3.2.31
MEDLINE Enzyme Link: MEDLINE 6.3.2.31

EC number:6.3.2.31

MSA:

6.3.2.31;
Phylogenetic Tree:

6.3.2.31;
Uniprot:
M-CSA:
RHEA:30555 GTP + L-glutamate + oxidized F420-0 = GDP + H(+) + oxidized coenzyme F420-1 + phosphate
RULE(radius=1) [*:1]-[NH2;+0:2].[*:3]-[O;H0;+0:4]-[P;H0;+0:5](-[*:6])(=[*:7])-[*:8].[*:9]=[C;H0;+0:10](-[*:11])-[OH;+0:12]>>[*:3]-[OH;+0:4].[*:6]-[P;H0;+0:5](=[*:7])(-[*:8])-[OH;+0:12].[*:9]=[C;H0;+0:10](-[*:11])-[NH;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Structure of an amide bond forming F(420):gamma-glutamyl ligase from Archaeoglobus fulgidus -- a member of a new family of non-ribosomal peptide synthases.Nocek B, Evdokimova E, Proudfoot M, Kudritska M, Grochowski LL, White RH, Savchenko A, Yakunin AF, Edwards A, Joachimiak A2007 Sep 1417669425
CofE catalyzes the addition of two glutamates to F420-0 in F420 coenzyme biosynthesis in Methanococcus jannaschii.Li H, Graupner M, Xu H, White RH2003 Aug 1912911320