EC number:6.3.2.35

Enzyme

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EC Tree
     6. Ligases
        6.3 Forming carbon-nitrogen bonds
            6.3.2 Acid-D-amino-acid ligases (peptide synthases)
ID:6.3.2.35
Description:D-alanine--D-serine ligase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.3.2.35
BRENDA Enzyme Link: BRENDA 6.3.2.35
KEGG Enzyme Link: KEGG6.3.2.35
BioCyc Enzyme Link: BioCyc 6.3.2.35
ExPASy Enzyme Link: ExPASy6.3.2.35
EC2PDB Enzyme Link: EC2PDB 6.3.2.35
ExplorEnz Enzyme Link: ExplorEnz 6.3.2.35
PRIAM enzyme-specific profiles Link: PRIAM 6.3.2.35
IntEnz Enzyme Link: IntEnz 6.3.2.35
MEDLINE Enzyme Link: MEDLINE 6.3.2.35

EC number:6.3.2.35

MSA:

6.3.2.35;
Phylogenetic Tree:

6.3.2.35;
Uniprot:
M-CSA:
RHEA:27706 ATP + D-alanine + D-serine = ADP + D-alanyl-D-serine + H(+) + phosphate
RULE(radius=1) [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[OH;+0:6].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[O;H0;+0:11]-[*:12]>>[*:1]-[NH;+0:2]-[C;H0;+0:4](=[*:3])-[*:5].[*:12]-[OH;+0:11].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[OH;+0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Bacterial resistance to vancomycin: overproduction, purification, and characterization of VanC2 from Enterococcus casseliflavus as a D-Ala-D-Ser ligase.Park IS, Lin CH, Walsh CT1997 Sep 169294159
Sequence of the vanC gene of Enterococcus gallinarum BM4174 encoding a D-alanine:D-alanine ligase-related protein necessary for vancomycin resistance.Dutka-Malen S, Molinas C, Arthur M, Courvalin P1992 Mar 11551598