EC number:6.3.2.37

Enzyme

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     6. Ligases
        6.3 Forming carbon-nitrogen bonds
            6.3.2 Acid-D-amino-acid ligases (peptide synthases)
ID:6.3.2.37
Description:UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysine ligase.
Alternative Name: UDP-MurNAc-L-Ala-D-Glu:D-Lys ligase.
D-lysine-adding enzyme.
Cath: 3.40.1190.10; 3.40.1390.10; 3.90.190.20;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.3.2.37
BRENDA Enzyme Link: BRENDA 6.3.2.37
KEGG Enzyme Link: KEGG6.3.2.37
BioCyc Enzyme Link: BioCyc 6.3.2.37
ExPASy Enzyme Link: ExPASy6.3.2.37
EC2PDB Enzyme Link: EC2PDB 6.3.2.37
ExplorEnz Enzyme Link: ExplorEnz 6.3.2.37
PRIAM enzyme-specific profiles Link: PRIAM 6.3.2.37
IntEnz Enzyme Link: IntEnz 6.3.2.37
MEDLINE Enzyme Link: MEDLINE 6.3.2.37

EC number:6.3.2.37

MSA:

6.3.2.37;
Phylogenetic Tree:

6.3.2.37;
Uniprot:
M-CSA:
RHEA:25273 ATP + D-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + N(6)-(UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl)-D-lysine + phosphate
RULE(radius=1) [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[OH;+0:6].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[O;H0;+0:11]-[*:12]>>[*:12]-[OH;+0:11].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[OH;+0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
The MurE synthetase from Thermotoga maritima is endowed with an unusual D-lysine adding activity.Boniface A, Bouhss A, Mengin-Lecreulx D, Blanot D2006 Jun 916595662