EC number:6.3.2.39
Enzyme
Download| EC Tree |
| 6. Ligases |
| 6.3 Forming carbon-nitrogen bonds |
| 6.3.2 Acid-D-amino-acid ligases (peptide synthases) |
| ID: | 6.3.2.39 |
|---|---|
| Description: | Aerobactin synthase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 6.3.2.39 |
| BRENDA Enzyme Link: | BRENDA 6.3.2.39 |
| KEGG Enzyme Link: | KEGG6.3.2.39 |
| BioCyc Enzyme Link: | BioCyc 6.3.2.39 |
| ExPASy Enzyme Link: | ExPASy6.3.2.39 |
| EC2PDB Enzyme Link: | EC2PDB 6.3.2.39 |
| ExplorEnz Enzyme Link: | ExplorEnz 6.3.2.39 |
| PRIAM enzyme-specific profiles Link: | PRIAM 6.3.2.39 |
| IntEnz Enzyme Link: | IntEnz 6.3.2.39 |
| MEDLINE Enzyme Link: | MEDLINE 6.3.2.39 |
| RHEA:32167 | 2 ATP + H2O + N(2)-citryl-N(6)-acetyl-N(6)-hydroxylysine + N(6)-acetyl-N(6)-hydroxy-L-lysine = 2 ADP + aerobactin + 2 H(+) + 2 phosphate |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[OH;+0:6].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[O;H0;+0:11]-[*:12].[*:13]=[P;H0;+0:14](-[*:15])(-[*:16])-[O;H0;+0:17]-[*:18].[OH2;+0:19]>>[*:12]-[OH;+0:11].[*:18]-[OH;+0:17].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[OH;+0:19].[*:13]=[P;H0;+0:14](-[*:15])(-[*:16])-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The long-overlooked enzymology of a nonribosomal peptide synthetase-independent pathway for virulence-conferring siderophore biosynthesis. | Oves-Costales D, Kadi N, Challis GL | 2009 Nov 21 | 19865642 |
| The isolation and characterization of a hydroxamic acid (aerobactin) formed by Aerobacter aerogenes 62-I. | Gibson F, Magrath DI | 1969 Nov 18 | 4313071 |
| Characterization of iucA and iucC genes of the aerobactin system of plasmid ColV-K30 in Escherichia coli. | de Lorenzo V, Neilands JB | 1986 Jul | 3087960 |
| A widely distributed bacterial pathway for siderophore biosynthesis independent of nonribosomal peptide synthetases. | Challis GL | 2005 Apr | 15719346 |
| Identification and characterization of two contiguous operons required for aerobactin transport and biosynthesis in Vibrio mimicus. | Moon YH, Tanabe T, Funahashi T, Shiuchi K, Nakao H, Yamamoto S | 2004 | 15215626 |
| Aerobactin biosynthesis and transport genes of plasmid ColV-K30 in Escherichia coli K-12. | de Lorenzo V, Bindereif A, Paw BH, Neilands JB | 1986 Feb | 2935523 |