EC number:6.3.2.40
Enzyme
Download| EC Tree |
| 6. Ligases |
| 6.3 Forming carbon-nitrogen bonds |
| 6.3.2 Acid-D-amino-acid ligases (peptide synthases) |
| ID: | 6.3.2.40 |
|---|---|
| Description: | Cyclopeptine synthase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 6.3.2.40 |
| BRENDA Enzyme Link: | BRENDA 6.3.2.40 |
| KEGG Enzyme Link: | KEGG6.3.2.40 |
| BioCyc Enzyme Link: | BioCyc 6.3.2.40 |
| ExPASy Enzyme Link: | ExPASy6.3.2.40 |
| EC2PDB Enzyme Link: | EC2PDB 6.3.2.40 |
| ExplorEnz Enzyme Link: | ExplorEnz 6.3.2.40 |
| PRIAM enzyme-specific profiles Link: | PRIAM 6.3.2.40 |
| IntEnz Enzyme Link: | IntEnz 6.3.2.40 |
| MEDLINE Enzyme Link: | MEDLINE 6.3.2.40 |
| RHEA:35091 | anthranilate + 2 ATP + L-phenylalanine + S-adenosyl-L-methionine = 2 AMP + cyclopeptine + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](-[*:4])(=[*:5])-[*:6].[*:7]-[P;H0;+0:8](=[*:9])(-[*:10])-[O;H0;+0:11]-[*:12].[*:13]-[S+;H0:14](-[*:15])-[CH3;+0:16].[*:17]=[C;H0;+0:18](-[OH;+0:19])-[*:20]-[NH2;+0:21].[*:22]=[C;H0;+0:23](-[OH;+0:24])-[*:25]:[*:26]-[NH2;+0:27]>>[*:1]-[OH;+0:2].[*:12]-[OH;+0:11].[*:4]-[P;H0;+0:3](=[*:5])(-[*:6])-[OH;+0:19].[*:7]-[P;H0;+0:8](=[*:9])(-[*:10])-[OH;+0:24].[*:13]-[S;H0;+0:14]-[*:15].[*:22]=[C;H0;+0:23]1-[*:25]:[*:26]-[NH;+0:27]-[C;H0;+0:18](=[*:17])-[*:20]-[N;H0;+0:21]-1-[CH3;+0:16] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cyclopeptine synthetase activity in surface cultures of Penicillium cyclopium. | Lerbs W, Luckner M | 1985 | 2995633 |
| Uric acid is a genuine metabolite of Penicillium cyclopium and stimulates the expression of alkaloid biosynthesis in this fungus. | Helbig F, Steighardt J, Roos W | 2002 Apr | 11916664 |