EC number:6.3.2.43

Enzyme

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     6. Ligases
        6.3 Forming carbon-nitrogen bonds
            6.3.2 Acid-D-amino-acid ligases (peptide synthases)
ID:6.3.2.43
Description:[Amino group carrier protein]--L-2-aminoadipate ligase.
Alternative Name: Alpha-aminoadipate-lysW ligase.
AAA--LysW ligase.
Cath: 3.30.1490.20; 3.30.470.80; 3.40.50.20;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.3.2.43
BRENDA Enzyme Link: BRENDA 6.3.2.43
KEGG Enzyme Link: KEGG6.3.2.43
BioCyc Enzyme Link: BioCyc 6.3.2.43
ExPASy Enzyme Link: ExPASy6.3.2.43
EC2PDB Enzyme Link: EC2PDB 6.3.2.43
ExplorEnz Enzyme Link: ExplorEnz 6.3.2.43
PRIAM enzyme-specific profiles Link: PRIAM 6.3.2.43
IntEnz Enzyme Link: IntEnz 6.3.2.43
MEDLINE Enzyme Link: MEDLINE 6.3.2.43

EC number:6.3.2.43

MSA:

6.3.2.43;
Phylogenetic Tree:

6.3.2.43;
Uniprot:
M-CSA:
RHEA:41940 [2-aminoadipate-carrier protein]-C-terminal-L-glutamate + ATP + L-2-aminoadipate = [2-aminoadipate-carrier protein]-C-terminal-gamma-(L-2-aminoadip-2-yl)-L-glutamate + ADP + H(+) + phosphate
RULE(radius=1) [*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:4].[*:5]-[NH2;+0:6].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[O;H0;+0:11]-[*:12]>>[*:1]-[C;H0;+0:2](=[*:3])-[NH;+0:6]-[*:5].[*:12]-[OH;+0:11].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[OH;+0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Lysine and arginine biosyntheses mediated by a common carrier protein in Sulfolobus.Ouchi T, Tomita T, Horie A, Yoshida A, Takahashi K, Nishida H, Lassak K, Taka H, Mineki R, Fujimura T, Kosono S, Nishiyama C, Masui R, Kuramitsu S, Albers SV, Kuzuyama T, Nishiyama M2013 Apr23434852
Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus.Horie A, Tomita T, Saiki A, Kono H, Taka H, Mineki R, Fujimura T, Nishiyama C, Kuzuyama T, Nishiyama M2009 Sep19620981
Cloning, expression, purification, crystallization and initial crystallographic analysis of the lysine-biosynthesis LysX protein from Thermus thermophilus HB8.Vassylyeva MN, Sakai H, Matsuura T, Sekine S, Nishiyama M, Terada T, Shirouzu M, Kuramitsu S, Vassylyev DG, Yokoyama S2003 Sep12925802