EC number:6.3.2.45
Enzyme
Download| EC Tree |
| 6. Ligases |
| 6.3 Forming carbon-nitrogen bonds |
| 6.3.2 Acid-D-amino-acid ligases (peptide synthases) |
| ID: | 6.3.2.45 |
|---|---|
| Description: | diaminoheptanedioate ligase. |
| Alternative Name: |
Murein peptide ligase. |
| Cath: | 3.40.1190.10; 3.40.50.720; 3.90.190.20; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 6.3.2.45 |
| BRENDA Enzyme Link: | BRENDA 6.3.2.45 |
| KEGG Enzyme Link: | KEGG6.3.2.45 |
| BioCyc Enzyme Link: | BioCyc 6.3.2.45 |
| ExPASy Enzyme Link: | ExPASy6.3.2.45 |
| EC2PDB Enzyme Link: | EC2PDB 6.3.2.45 |
| ExplorEnz Enzyme Link: | ExplorEnz 6.3.2.45 |
| PRIAM enzyme-specific profiles Link: | PRIAM 6.3.2.45 |
| IntEnz Enzyme Link: | IntEnz 6.3.2.45 |
| MEDLINE Enzyme Link: | MEDLINE 6.3.2.45 |
| RHEA:29563 | ATP + L-alanyl-gamma-D-glutamyl-meso-diaminopimelate + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminopimelate |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[OH;+0:6].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[O;H0;+0:11]-[*:12]>>[*:12]-[OH;+0:11].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Identification of the mpl gene encoding UDP-N-acetylmuramate: L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase in Escherichia coli and its role in recycling of cell wall peptidoglycan. | Mengin-Lecreulx D, van Heijenoort J, Park JT | 1996 Sep | 8808921 |
| Biochemical characterization and physiological properties of Escherichia coli UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase. | Hervé M, Boniface A, Gobec S, Blanot D, Mengin-Lecreulx D | 2007 Jun | 17384195 |