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6. Ligases

6.3 Forming carbon-nitrogen bonds

6.3.2 Acid-D-amino-acid ligases (peptide synthases)

ID:	6.3.2.49
Description:	L-alanine--L-anticapsin ligase.
Alternative Name:	L-Ala-L-anticapsin ligase. Alanine-anticapsin ligase.
Cath:	3.30.1490.20; 3.30.470.20; 3.90.1170.60; 3.40.50.20;

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UniProtKB Enzyme Link:	UniProtKB 6.3.2.49
BRENDA Enzyme Link:	BRENDA 6.3.2.49
KEGG Enzyme Link:	KEGG6.3.2.49
BioCyc Enzyme Link:	BioCyc 6.3.2.49
ExPASy Enzyme Link:	ExPASy6.3.2.49
EC2PDB Enzyme Link:	EC2PDB 6.3.2.49
ExplorEnz Enzyme Link:	ExplorEnz 6.3.2.49
PRIAM enzyme-specific profiles Link:	PRIAM 6.3.2.49
IntEnz Enzyme Link:	IntEnz 6.3.2.49
MEDLINE Enzyme Link:	MEDLINE 6.3.2.49

RHEA:44332	ATP + L-alanine + L-anticapsin = ADP + bacilysin + H(+) + phosphate
RULE(radius=1)	[:1]-[NH2;+0:2].[:3]=[C;H0;+0:4](-[:5])-[OH;+0:6].[:7]=[P;H0;+0:8](-[:9])(-[:10])-[O;H0;+0:11]-[:12]>>[:1]-[NH;+0:2]-[C;H0;+0:4](=[:3])-[:5].[:12]-[OH;+0:11].[:7]=[P;H0;+0:8](-[:9])(-[:10])-[OH;+0:6]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Single mutation alters the substrate specificity of L-amino acid ligase.	Tsuda T, Asami M, Koguchi Y, Kojima S	2014 Apr 29	24702628
Structural and enzymatic characterization of BacD, an L-amino acid dipeptide ligase from Bacillus subtilis.	Shomura Y, Hinokuchi E, Ikeda H, Senoo A, Takahashi Y, Saito J, Komori H, Shibata N, Yonetani Y, Higuchi Y	2012 May	22407814
ywfE in Bacillus subtilis codes for a novel enzyme, L-amino acid ligase.	Tabata K, Ikeda H, Hashimoto S	2005 Aug	16030213
Action and timing of BacC and BacD in the late stages of biosynthesis of the dipeptide antibiotic bacilysin.	Parker JB, Walsh CT	2013 Feb 5	23317005