EC number:6.3.2.5

Enzyme

Download
EC Tree
     6. Ligases
        6.3 Forming carbon-nitrogen bonds
            6.3.2 Acid-D-amino-acid ligases (peptide synthases)
ID:6.3.2.5
Description:Phosphopantothenate--cysteine ligase (CTP).
Alternative Name: Phosphopantothenoylcysteine synthetase.
Phosphopantothenate--cysteine ligase.
Cath: 3.40.50.10300;

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.
PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.3.2.5
BRENDA Enzyme Link: BRENDA 6.3.2.5
KEGG Enzyme Link: KEGG6.3.2.5
BioCyc Enzyme Link: BioCyc 6.3.2.5
ExPASy Enzyme Link: ExPASy6.3.2.5
EC2PDB Enzyme Link: EC2PDB 6.3.2.5
ExplorEnz Enzyme Link: ExplorEnz 6.3.2.5
PRIAM enzyme-specific profiles Link: PRIAM 6.3.2.5
IntEnz Enzyme Link: IntEnz 6.3.2.5
MEDLINE Enzyme Link: MEDLINE 6.3.2.5

EC number:6.3.2.5

MSA:

6.3.2.5;
Phylogenetic Tree:

6.3.2.5;
Uniprot:
M-CSA:
RHEA:19397 (R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine
RULE(radius=1) [*:1]-[NH2;+0:2].[*:3]-[O;H0;+0:4]-[P;H0;+0:5](-[*:6])(=[*:7])-[*:8].[*:9]=[C;H0;+0:10](-[*:11])-[OH;+0:12]>>[*:3]-[OH;+0:4].[*:6]-[P;H0;+0:5](=[*:7])(-[*:8])-[OH;+0:12].[*:9]=[C;H0;+0:10](-[*:11])-[NH;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Structural basis of CTP-dependent peptide bond formation in coenzyme A biosynthesis catalyzed by Escherichia coli PPC synthetase.Stanitzek S, Augustin MA, Huber R, Kupke T, Steinbacher S2004 Nov15530362