EC number:6.3.2.50

Enzyme

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EC Tree
     6. Ligases
        6.3 Forming carbon-nitrogen bonds
            6.3.2 Acid-D-amino-acid ligases (peptide synthases)
ID:6.3.2.50
Description:Tenuazonic acid synthetase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.3.2.50
BRENDA Enzyme Link: BRENDA 6.3.2.50
KEGG Enzyme Link: KEGG6.3.2.50
BioCyc Enzyme Link: BioCyc 6.3.2.50
ExPASy Enzyme Link: ExPASy6.3.2.50
EC2PDB Enzyme Link: EC2PDB 6.3.2.50
ExplorEnz Enzyme Link: ExplorEnz 6.3.2.50
PRIAM enzyme-specific profiles Link: PRIAM 6.3.2.50
IntEnz Enzyme Link: IntEnz 6.3.2.50
MEDLINE Enzyme Link: MEDLINE 6.3.2.50

EC number:6.3.2.50

MSA:

6.3.2.50;
Phylogenetic Tree:

6.3.2.50;
Uniprot:
M-CSA:
RHEA:52800 acetoacetyl-CoA + ATP + L-isoleucine = AMP + CoA + diphosphate + 2 H(+) + tenuazonic acid
RULE(radius=1) [*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[*:7]=[C;H0;+0:8](-[CH2;+0:9]-[*:10])-[S;H0;+0:11]-[*:12].[*:13]=[C;H0;+0:14](-[OH;+0:15])-[*:16]-[NH2;+0:17]>>[*:6]-[OH;+0:5].[*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[OH;+0:15].[*:12]-[SH;+0:11].[*:7]=[C;H0;+0:8]1-[NH;+0:17]-[*:16]-[C;H0;+0:14](=[*:13])-[CH;+0:9]-1-[*:10]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS-PKS hybrid enzyme.Yun CS, Motoyama T, Osada H2015 Oct 2726503170