EC number:6.3.2.51

Enzyme

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     6. Ligases
        6.3 Forming carbon-nitrogen bonds
            6.3.2 Acid-D-amino-acid ligases (peptide synthases)
ID:6.3.2.51
Description:Phosphopantothenate--cysteine ligase (ATP).
Alternative Name: Phosphopantothenoylcysteine synthetase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.3.2.51
BRENDA Enzyme Link: BRENDA 6.3.2.51
KEGG Enzyme Link: KEGG6.3.2.51
BioCyc Enzyme Link: BioCyc 6.3.2.51
ExPASy Enzyme Link: ExPASy6.3.2.51
EC2PDB Enzyme Link: EC2PDB 6.3.2.51
ExplorEnz Enzyme Link: ExplorEnz 6.3.2.51
PRIAM enzyme-specific profiles Link: PRIAM 6.3.2.51
IntEnz Enzyme Link: IntEnz 6.3.2.51
MEDLINE Enzyme Link: MEDLINE 6.3.2.51

EC number:6.3.2.51

MSA:

6.3.2.51;
Phylogenetic Tree:

6.3.2.51;
Uniprot:
M-CSA:
RHEA:25156 (R)-4'-phosphopantothenate + ATP + L-cysteine = AMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine
RULE(radius=1) [*:1]-[NH2;+0:2].[*:3]-[O;H0;+0:4]-[P;H0;+0:5](-[*:6])(=[*:7])-[*:8].[*:9]=[C;H0;+0:10](-[*:11])-[OH;+0:12]>>[*:3]-[OH;+0:4].[*:6]-[P;H0;+0:5](=[*:7])(-[*:8])-[OH;+0:12].[*:9]=[C;H0;+0:10](-[*:11])-[NH;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Structure of human phosphopantothenoylcysteine synthetase at 2.3 A resolution.Manoj N, Strauss E, Begley TP, Ealick SE2003 Aug12906824
4'-phosphopantetheine and coenzyme A biosynthesis in plants.Kupke T, Hernández-Acosta P, Culiáñez-Macià FA2003 Oct 312860978
Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics.Daugherty M, Polanuyer B, Farrell M, Scholle M, Lykidis A, de Crécy-Lagard V, Osterman A2002 Jun 1411923312