EC number:6.3.2.6
Enzyme
Download| EC Tree |
| 6. Ligases |
| 6.3 Forming carbon-nitrogen bonds |
| 6.3.2 Acid-D-amino-acid ligases (peptide synthases) |
| ID: | 6.3.2.6 |
|---|---|
| Description: | Phosphoribosylaminoimidazolesuccinocarboxamide synthase. |
| Alternative Name: |
SAICARs. SAICAR synthetase. SAICAR synthase. Phosphoribosylaminoimidazolesuccinocarboxamide synthetase. Phosphoribosylaminoimidazole-succinocarboxamide synthetase. Phosphoribosylaminoimidazole-succinocarboxamide synthase. 5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase. 4-(N-succinocarboxamide)-5-aminoimidazole synthetase. 4-((N-succinylamino)carbonyl)-5-aminoimidazole ribonucleotide synthetase. |
| Prosite: | PDOC00810; |
| PDB: |
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| Cath: | 3.30.200.20; 3.30.470.20; 3.40.50.7700; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 6.3.2.6 |
| BRENDA Enzyme Link: | BRENDA 6.3.2.6 |
| KEGG Enzyme Link: | KEGG6.3.2.6 |
| BioCyc Enzyme Link: | BioCyc 6.3.2.6 |
| ExPASy Enzyme Link: | ExPASy6.3.2.6 |
| EC2PDB Enzyme Link: | EC2PDB 6.3.2.6 |
| ExplorEnz Enzyme Link: | ExplorEnz 6.3.2.6 |
| PRIAM enzyme-specific profiles Link: | PRIAM 6.3.2.6 |
| IntEnz Enzyme Link: | IntEnz 6.3.2.6 |
| MEDLINE Enzyme Link: | MEDLINE 6.3.2.6 |
| RHEA:22628 | 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[OH;+0:6].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[O;H0;+0:11]-[*:12]>>[*:12]-[OH;+0:11].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Identification of the purC gene product of Escherichia coli. | Parker J | 1984 Mar | 6365889 |
| Cloning and characterization of a 12-gene cluster from Bacillus subtilis encoding nine enzymes for de novo purine nucleotide synthesis. | Ebbole DJ, Zalkin H | 1987 Jun 15 | 3036807 |
| Cloning of a chicken liver cDNA encoding 5-aminoimidazole ribonucleotide carboxylase and 5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase by functional complementation of Escherichia coli pur mutants. | Chen ZD, Dixon JE, Zalkin H | 1990 Apr | 1691501 |
| Mechanism of action of Escherichia coli phosphoribosylaminoimidazolesuccinocarboxamide synthetase. | Nelson SW, Binkowski DJ, Honzatko RB, Fromm HJ | 2005 Jan 18 | 15641804 |
| Biosynthesis of the purines. XXIV. The enzymatic synthesis of 5-amino-1-ribosyl-4-imidazolecarboxylic acid 5'-phosphate from 5-amino-1-ribosylimidazole 5'-phosphate and carbon dioxide. | LUKENS LN, BUCHANAN JM | 1959 Jul | 13672967 |
| The Drosophila melanogaster ade5 gene encodes a bifunctional enzyme for two steps in the de novo purine synthesis pathway. | O'Donnell AF, Tiong S, Nash D, Clark DV | 2000 Mar | 10757766 |