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6. Ligases

6.3 Forming carbon-nitrogen bonds

6.3.2 Acid-D-amino-acid ligases (peptide synthases)

ID:	6.3.2.7
Description:	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase.
Alternative Name:	Uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine synthetase. UPD-MurNAc-L-Ala-D-Glu:L-Lys ligase. UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase. MurE synthetase. L-lysine-adding enzyme.
Cath:	3.30.1490.20; 3.30.470.20; 3.40.1190.10; 3.40.1390.10; 3.90.190.20; 3.40.50.20;

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UniProtKB Enzyme Link:	UniProtKB 6.3.2.7
BRENDA Enzyme Link:	BRENDA 6.3.2.7
KEGG Enzyme Link:	KEGG6.3.2.7
BioCyc Enzyme Link:	BioCyc 6.3.2.7
ExPASy Enzyme Link:	ExPASy6.3.2.7
EC2PDB Enzyme Link:	EC2PDB 6.3.2.7
ExplorEnz Enzyme Link:	ExplorEnz 6.3.2.7
PRIAM enzyme-specific profiles Link:	PRIAM 6.3.2.7
IntEnz Enzyme Link:	IntEnz 6.3.2.7
MEDLINE Enzyme Link:	MEDLINE 6.3.2.7

RHEA:17969	ATP + L-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine
RULE(radius=1)	[:1]-[NH2;+0:2].[:3]=[C;H0;+0:4](-[:5])-[OH;+0:6].[:7]=[P;H0;+0:8](-[:9])(-[:10])-[O;H0;+0:11]-[:12]>>[:12]-[OH;+0:11].[:3]=[C;H0;+0:4](-[:5])-[NH;+0:2]-[:1].[:7]=[P;H0;+0:8](-[:9])(-[:10])-[OH;+0:6]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
ENZYMATIC SYNTHESIS OF THE PEPTIDE IN BACTERIAL URIDINE NUCLEOTIDES. III. PURIFICATION AND PROPERTIES OF L-LYSIN-ADDING ENZYME.	ITO E, STROMINGER JL	1964 Jan	14114846
Recent advances in the formation of the bacterial peptidoglycan monomer unit.	van Heijenoort J	2001 Oct	11699883