EC number:6.3.2.8

Enzyme

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     6. Ligases
        6.3 Forming carbon-nitrogen bonds
            6.3.2 Acid-D-amino-acid ligases (peptide synthases)
ID:6.3.2.8
Description:UDP-N-acetylmuramate--L-alanine ligase.
Alternative Name: Uridine-diphosphate-N-acetylmuramate:L-alanine ligase.
Uridine diphospho-N-acetylmuramoylalanine synthetase.
Uridine diphosphate N-acetylmuramate:L-alanine ligase.
Uridine 5'-diphosphate-N-acetylmuramyl-L-alanine synthetase.
UDPMurNAc-L-alanine synthetase.
UDP-N-acetylmuramyl:L-alanine ligase.
UDP-N-acetylmuramoylalanine synthetase.
UDP-N-acetylmuramoyl-L-alanine synthetase.
UDP-MurNAc:L-alanine ligase.
UDP-acetylmuramyl-L-alanine synthetase.
MurC synthetase.
L-alanine-adding enzyme.
L-Ala ligase.
Alanine-adding enzyme.
Prosite: PDOC50975;
PDB:
PDBScop
Cath: 3.30.1490.20; 3.30.470.20; 3.40.1190.10; 3.40.1390.10; 3.40.50.720; 3.90.190.20; 3.40.50.20;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.3.2.8
BRENDA Enzyme Link: BRENDA 6.3.2.8
KEGG Enzyme Link: KEGG6.3.2.8
BioCyc Enzyme Link: BioCyc 6.3.2.8
ExPASy Enzyme Link: ExPASy6.3.2.8
EC2PDB Enzyme Link: EC2PDB 6.3.2.8
ExplorEnz Enzyme Link: ExplorEnz 6.3.2.8
PRIAM enzyme-specific profiles Link: PRIAM 6.3.2.8
IntEnz Enzyme Link: IntEnz 6.3.2.8
MEDLINE Enzyme Link: MEDLINE 6.3.2.8

EC number:6.3.2.8

MSA:

6.3.2.8;
Phylogenetic Tree:

6.3.2.8;
Uniprot:
M-CSA:
RHEA:23372 ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine
RULE(radius=1) [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[OH;+0:6].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[O;H0;+0:11]-[*:12]>>[*:12]-[OH;+0:11].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[OH;+0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Recent advances in the formation of the bacterial peptidoglycan monomer unit.van Heijenoort J2001 Oct11699883
Biochemical evidence for the formation of a covalent acyl-phosphate linkage between UDP-N-acetylmuramate and ATP in the Escherichia coli UDP-N-acetylmuramate:L-alanine ligase-catalyzed reaction.Falk PJ, Ervin KM, Volk KS, Ho HT1996 Feb 68634271
ENZYMATIC SYNTHESIS OF THE PEPTIDE IN BACTERIAL URIDINE NUCLEOTIDES. IV. PURIFICATION AND PROPERTIES OF D-GLUTAMIC ACID-ADDING ENZYME.NATHENSON SG, STROMINGER JL, ITO E1964 Jun14213349