EC number:6.3.2.9
Enzyme
Download| EC Tree |
| 6. Ligases |
| 6.3 Forming carbon-nitrogen bonds |
| 6.3.2 Acid-D-amino-acid ligases (peptide synthases) |
| ID: | 6.3.2.9 |
|---|---|
| Description: | UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase. |
| Alternative Name: |
Uridine diphospho-N-acetylmuramoylalanyl-D-glutamate synthetase. UDP-N-acetylmuramoylalanine--D-glutamate ligase. UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase. UDP-Mur-NAC-L-Ala:D-Glu ligase. MurD synthetase. D-glutamate-adding enzyme. D-glutamate ligase. |
| Cath: | 3.30.1490.20; 3.30.470.20; 3.40.1190.10; 3.40.1390.10; 3.40.50.720; 3.90.190.20; 3.40.50.20; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 6.3.2.9 |
| BRENDA Enzyme Link: | BRENDA 6.3.2.9 |
| KEGG Enzyme Link: | KEGG6.3.2.9 |
| BioCyc Enzyme Link: | BioCyc 6.3.2.9 |
| ExPASy Enzyme Link: | ExPASy6.3.2.9 |
| EC2PDB Enzyme Link: | EC2PDB 6.3.2.9 |
| ExplorEnz Enzyme Link: | ExplorEnz 6.3.2.9 |
| PRIAM enzyme-specific profiles Link: | PRIAM 6.3.2.9 |
| IntEnz Enzyme Link: | IntEnz 6.3.2.9 |
| MEDLINE Enzyme Link: | MEDLINE 6.3.2.9 |
| RHEA:16429 | ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[OH;+0:6].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[O;H0;+0:11]-[*:12]>>[*:12]-[OH;+0:11].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cloning and expression of Staphylococcus aureus and Treptococcus pyogenes murD genes encoding uridine diphosphate N-acetylmuramoyl-L-alanine:D-glutamate ligases. | El-Sherbeini M, Geissler WM, Pittman J, Yuan X, Wong KK, Pompliano DL | 1998 Mar 27 | 9524242 |
| Study of the reaction mechanism of the D-glutamic acid-adding enzyme from Escherichia coli. | Vaganay S, Tanner ME, van Heijenoort J, Blanot D | 1996 Spring | 9158722 |
| MurD ligase from E. coli: Tetrahedral intermediate formation study by hybrid quantum mechanical/molecular mechanical replica path method. | Perdih A, Hodoscek M, Solmajer T | 2009 Feb 15 | 18704940 |
| Recent advances in the formation of the bacterial peptidoglycan monomer unit. | van Heijenoort J | 2001 Oct | 11699883 |