EC number:6.3.3.1
| ID: | 6.3.3.1 |
|---|---|
| Description: | Phosphoribosylformylglycinamidine cyclo-ligase. |
| Alternative Name: |
Phosphoribosylaminoimidazole synthetase. Phosphoribosyl-aminoimidazole synthetase. AIRS. AIR synthetase. AIR synthase. |
| Cath: | 3.30.1330.10; 3.30.1490.20; 3.30.470.20; 3.90.600.10; 3.90.650.10; 3.40.50.170; 3.40.50.20; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 6.3.3.1 |
| BRENDA Enzyme Link: | BRENDA 6.3.3.1 |
| KEGG Enzyme Link: | KEGG6.3.3.1 |
| BioCyc Enzyme Link: | BioCyc 6.3.3.1 |
| ExPASy Enzyme Link: | ExPASy6.3.3.1 |
| EC2PDB Enzyme Link: | EC2PDB 6.3.3.1 |
| ExplorEnz Enzyme Link: | ExplorEnz 6.3.3.1 |
| PRIAM enzyme-specific profiles Link: | PRIAM 6.3.3.1 |
| IntEnz Enzyme Link: | IntEnz 6.3.3.1 |
| MEDLINE Enzyme Link: | MEDLINE 6.3.3.1 |
| RHEA:23032 | 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + H(+) + phosphate |
| RULE(radius=1) | [*:1]-[NH;+0:2]-[C;H0;+0:3](=[NH;+0:4])-[CH2;+0:5]-[NH;+0:6]-[CH;+0:7]=[O;H0;+0:8].[*:9]=[P;H0;+0:10](-[*:11])(-[*:12])-[O;H0;+0:13]-[*:14]>>[*:14]-[OH;+0:13].[*:1]-[n;H0;+0:2]1:[cH;+0:7]:[n;H0;+0:6]:[cH;+0:5]:[c;H0;+0:3]:1-[NH2;+0:4].[*:9]=[P;H0;+0:10](-[*:11])(-[*:12])-[OH;+0:8] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural biology of the purine biosynthetic pathway. | Zhang Y, Morar M, Ealick SE | 2008 Nov | 18712276 |
| Biosynthesis of the purines. XIII. Structure, enzymatic synthesis, and metabolism of (alpha-N-formyl)-glycinamidine ribotide. | LEVENBERG B, BUCHANAN JM | 1957 Feb | 13405930 |
| Biosynthesis of the purines. XII. Structure, enzymatic synthesis, and metabolism of 5-amino-imidazole ribotide. | LEVENBERG B, BUCHANAN JM | 1957 Feb | 13405929 |