EnzyMine

Download

EC Tree

6. Ligases

6.3 Forming carbon-nitrogen bonds

6.3.3 Cyclo-ligases

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.

PDB	Click once to unfold,double click to fold.

UniProtKB Enzyme Link:	UniProtKB 6.3.3.3
BRENDA Enzyme Link:	BRENDA 6.3.3.3
KEGG Enzyme Link:	KEGG6.3.3.3
BioCyc Enzyme Link:	BioCyc 6.3.3.3
ExPASy Enzyme Link:	ExPASy6.3.3.3
EC2PDB Enzyme Link:	EC2PDB 6.3.3.3
ExplorEnz Enzyme Link:	ExplorEnz 6.3.3.3
PRIAM enzyme-specific profiles Link:	PRIAM 6.3.3.3
IntEnz Enzyme Link:	IntEnz 6.3.3.3
MEDLINE Enzyme Link:	MEDLINE 6.3.3.3

RHEA:15805	7,8-diaminononanoate + ATP + CO2 = ADP + dethiobiotin + 3 H(+) + phosphate
RULE(radius=1)	[:1]=[C;H0;+0:2]=[O;H0;+0:3].[:4]=[P;H0;+0:5](-[:6])(-[:7])-[O;H0;+0:8]-[:9].[NH2;+0:10]-[:11]-[:12]-[NH2;+0:13]>>[:9]-[OH;+0:8].[:1]=[C;H0;+0:2]1-[NH;+0:10]-[:11]-[:12]-[NH;+0:13]-1.[:4]=[P;H0;+0:5](-[:6])(-[:7])-[OH;+0:3]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Crystal structure of two quaternary complexes of dethiobiotin synthetase, enzyme-MgADP-AlF3-diaminopelargonic acid and enzyme-MgADP-dethiobiotin-phosphate; implications for catalysis.	Käck H, Sandmark J, Gibson KJ, Schneider G, Lindqvist Y	1998 Dec	9865950
Snapshot of a phosphorylated substrate intermediate by kinetic crystallography.	Käck H, Gibson KJ, Lindqvist Y, Schneider G	1998 May 12	9576910
Active site mutants of Escherichia coli dethiobiotin synthetase: effects of mutations on enzyme catalytic and structural properties.	Yang G, Sandalova T, Lohman K, Lindqvist Y, Rendina AR	1997 Apr 22	9125495
The purification and properties of dethiobiotin synthetase.	Krell K, Eisenberg MA	1970 Dec 25	4921568