EC number:6.3.3.7
| ID: | 6.3.3.7 |
|---|---|
| Description: | Ni-sirohydrochlorin a,c-diamide reductive cyclase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 6.3.3.7 |
| BRENDA Enzyme Link: | BRENDA 6.3.3.7 |
| KEGG Enzyme Link: | KEGG6.3.3.7 |
| BioCyc Enzyme Link: | BioCyc 6.3.3.7 |
| ExPASy Enzyme Link: | ExPASy6.3.3.7 |
| EC2PDB Enzyme Link: | EC2PDB 6.3.3.7 |
| ExplorEnz Enzyme Link: | ExplorEnz 6.3.3.7 |
| PRIAM enzyme-specific profiles Link: | PRIAM 6.3.3.7 |
| IntEnz Enzyme Link: | IntEnz 6.3.3.7 |
| MEDLINE Enzyme Link: | MEDLINE 6.3.3.7 |
| RHEA:52900 | 3 AH2 + ATP + H2O + Ni-sirohydrochlorin a,c-diamide = 15,17(3)-seco-F430-17(3)-acid + 3 A + ADP + phosphate |
| RULE(radius=1) | ([*:1]-[NH2;+0:2].[*:3]-[c;H0;+0:4]1:[c;H0;+0:5]2:[n;H0;+0:6]3:[c;H0;+0:7](:[c;H0;+0:8]:1-[*:9])-[CH;+0:10]=[C;H0;+0:11]1-[*:12]-[*:13]-[C;H0;+0:14]4=[N+;H0:15]-1-[*:16]-31-[N+;H0:17]3=[C;H0;+0:18](-[CH;+0:19]=[C;H0;+0:20]5-[*:21]-[*:22]-[C;H0;+0:23](=[CH;+0:24]-4)-[N;H0;+0:25]-5-1)-[C;H0;+0:26](-[*:27])=[C;H0;+0:28](-[*:29])-[*:30]-3=[*:31]-2).[*:32]=[P;H0;+0:33](-[*:34])(-[*:35])-[O;H0;+0:36]-[*:37].[OH2;+0:38]>>[*:3]-[CH;+0:4]1-[C;H0;+0:5]2=[N+;H0:6]3-[CH;+0:7](-[CH2;+0:10]-[C;H0;+0:11]4=[N+;H0:15]5-[CH;+0:14](-[*:13]-[*:12]-4)-[CH2;+0:24]-[C;H0;+0:23]4(-[NH;+0:2]-[*:1])-[*:22]-[*:21]-[C;H0;+0:20]6=[N+;H0:25]-4-[*:16]-3-5-[N;H0;+0:17]3-[*:30](=[*:31]-2)-[CH;+0:28](-[*:29])-[CH;+0:26](-[*:27])-[C;H0;+0:18]-3=[CH;+0:19]-6)-[CH;+0:8]-1-[*:9].[*:37]-[OH;+0:36].[*:32]=[P;H0;+0:33](-[*:34])(-[*:35])-[OH;+0:38] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Biosynthesis of coenzyme F430 in methanogenic bacteria. Identification of 15,17(3)-seco-F430-17(3)-acid as an intermediate. | Pfaltz A, Kobelt A, Hüster R, Thauer RK | 1987 Dec 30 | 3691535 |
| The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea. | Zheng K, Ngo PD, Owens VL, Yang XP, Mansoorabadi SO | 2016 Oct 21 | 27846569 |