EC number:6.3.4.10

Enzyme

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     6. Ligases
        6.3 Forming carbon-nitrogen bonds
            6.3.4 Other carbon-nitrogen ligases
ID:6.3.4.10
Description:Biotin--[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase.
Alternative Name: Propionyl-CoA holocarboxylase synthetase.
Holocarboxylase synthetase.
Biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] synthetase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.3.4.10
BRENDA Enzyme Link: BRENDA 6.3.4.10
KEGG Enzyme Link: KEGG6.3.4.10
BioCyc Enzyme Link: BioCyc 6.3.4.10
ExPASy Enzyme Link: ExPASy6.3.4.10
EC2PDB Enzyme Link: EC2PDB 6.3.4.10
ExplorEnz Enzyme Link: ExplorEnz 6.3.4.10
PRIAM enzyme-specific profiles Link: PRIAM 6.3.4.10
IntEnz Enzyme Link: IntEnz 6.3.4.10
MEDLINE Enzyme Link: MEDLINE 6.3.4.10

EC number:6.3.4.10

MSA:

6.3.4.10;
Phylogenetic Tree:

6.3.4.10;
Uniprot:
M-CSA:
RHEA:11204 apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin = AMP + diphosphate + H(+) + holo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]
RULE(radius=1) [*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:4].[*:5]-[NH2;+0:6].[*:7]-[O;H0;+0:8]-[P;H0;+0:9](-[*:10])(=[*:11])-[*:12]>>[*:1]-[C;H0;+0:2](=[*:3])-[NH;+0:6]-[*:5].[*:7]-[OH;+0:8].[*:10]-[P;H0;+0:9](=[*:11])(-[*:12])-[OH;+0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Mutations in the holocarboxylase synthetase gene HLCS.Suzuki Y, Yang X, Aoki Y, Kure S, Matsubara Y2005 Oct16134170
THE ENZYMATIC SYNTHESIS OF PROPIONYL COENZYME A HOLOCARBOXYLASE FROM D-BIOTINYL 5'-ADENYLATE AND THE APOCARBOXYLASE.SIEGEL L, FOOTE JL, COON MJ1965 Mar14284697
Relationship between kinetic properties of mutant enzyme and biochemical and clinical responsiveness to biotin in holocarboxylase synthetase deficiency.Sakamoto O, Suzuki Y, Li X, Aoki Y, Hiratsuka M, Suormala T, Baumgartner ER, Gibson KM, Narisawa K1999 Dec10590022