EC number:6.3.4.11

Enzyme

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     6. Ligases
        6.3 Forming carbon-nitrogen bonds
            6.3.4 Other carbon-nitrogen ligases
ID:6.3.4.11
Description:Biotin--[methylcrotonoyl-CoA-carboxylase] ligase.
Alternative Name: Biotin--[methylcrotonoyl-CoA-carboxylase] synthetase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.3.4.11
BRENDA Enzyme Link: BRENDA 6.3.4.11
KEGG Enzyme Link: KEGG6.3.4.11
BioCyc Enzyme Link: BioCyc 6.3.4.11
ExPASy Enzyme Link: ExPASy6.3.4.11
EC2PDB Enzyme Link: EC2PDB 6.3.4.11
ExplorEnz Enzyme Link: ExplorEnz 6.3.4.11
PRIAM enzyme-specific profiles Link: PRIAM 6.3.4.11
IntEnz Enzyme Link: IntEnz 6.3.4.11
MEDLINE Enzyme Link: MEDLINE 6.3.4.11

EC number:6.3.4.11

MSA:

6.3.4.11;
Phylogenetic Tree:

6.3.4.11;
Uniprot:
M-CSA:
RHEA:24376 apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin = AMP + diphosphate + H(+) + holo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]
RULE(radius=1) [*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:4].[*:5]-[NH2;+0:6].[*:7]-[O;H0;+0:8]-[P;H0;+0:9](-[*:10])(=[*:11])-[*:12]>>[*:1]-[C;H0;+0:2](=[*:3])-[NH;+0:6]-[*:5].[*:7]-[OH;+0:8].[*:10]-[P;H0;+0:9](=[*:11])(-[*:12])-[OH;+0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
[Synthesis of biotin in beta-methylcrotonyl-CoA-carboxylase by holocarboxylase synthetase].Höpner T, Knappe J1965 Jul 225867144
Selectivity in post-translational biotin addition to five human carboxylases.Ingaramo M, Beckett D2012 Jan 1322123817
The enzymatic biotinylation of proteins: a post-translational modification of exceptional specificity.Chapman-Smith A, Cronan JE Jr1999 Sep10470036