EC number:6.3.4.13
Enzyme
Download| EC Tree |
| 6. Ligases |
| 6.3 Forming carbon-nitrogen bonds |
| 6.3.4 Other carbon-nitrogen ligases |
| ID: | 6.3.4.13 | ||||||||||||||||
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| Description: | Phosphoribosylamine--glycine ligase. | ||||||||||||||||
| Alternative Name: |
Phosphoribosylglycinamide synthetase. Glycinamide ribonucleotide synthetase. GARS. GAR synthetase. | ||||||||||||||||
| Prosite: | PDOC50975; PDOC00164; | ||||||||||||||||
| PDB: |
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| Cath: | 3.30.1330.10; 3.30.1490.20; 3.30.470.20; 3.90.600.10; 3.90.650.10; 3.40.50.170; 3.40.50.20; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 6.3.4.13 |
| BRENDA Enzyme Link: | BRENDA 6.3.4.13 |
| KEGG Enzyme Link: | KEGG6.3.4.13 |
| BioCyc Enzyme Link: | BioCyc 6.3.4.13 |
| ExPASy Enzyme Link: | ExPASy6.3.4.13 |
| EC2PDB Enzyme Link: | EC2PDB 6.3.4.13 |
| ExplorEnz Enzyme Link: | ExplorEnz 6.3.4.13 |
| PRIAM enzyme-specific profiles Link: | PRIAM 6.3.4.13 |
| IntEnz Enzyme Link: | IntEnz 6.3.4.13 |
| MEDLINE Enzyme Link: | MEDLINE 6.3.4.13 |
| RHEA:17453 | 5-phospho-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[OH;+0:6].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[O;H0;+0:11]-[*:12]>>[*:1]-[NH;+0:2]-[C;H0;+0:4](=[*:3])-[*:5].[*:12]-[OH;+0:11].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| De novo purine nucleotide biosynthesis: cloning of human and avian cDNAs encoding the trifunctional glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase by functional complementation in E. coli. | Aimi J, Qiu H, Williams J, Zalkin H, Dixon JE | 1990 Nov 25 | 2147474 |
| Biosynthesis of the purines. XXII. 2-Amino-N-ribosylacetamide-5'-phosphate kinosynthase. | HARTMAN SC, BUCHANAN JM | 1958 Aug | 13563520 |
| On the mechanism of synthesis of glycinamide ribotide and its formyl derivative. | GOLDTHWAIT DA, GREENBERG GR, PEABODY RA | 1956 Aug | 13357451 |
| Localization of GAR transformylase in Escherichia coli and mammalian cells. | Gooljarsingh LT, Ramcharan J, Gilroy S, Benkovic SJ | 2001 Jun 5 | 11381136 |