EC number:6.3.4.14
Enzyme
Download| EC Tree |
| 6. Ligases |
| 6.3 Forming carbon-nitrogen bonds |
| 6.3.4 Other carbon-nitrogen ligases |
| ID: | 6.3.4.14 | ||
|---|---|---|---|
| Description: | Biotin carboxylase. | ||
| Prosite: | PDOC50975; | ||
| PDB: |
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| Cath: | 3.30.1490.20; 3.30.1490.460; 3.30.470.20; 3.90.1770.10; 3.90.226.10; 2.40.460.10; 2.40.50.100; 3.40.50.12210; 3.40.50.20; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 6.3.4.14 |
| BRENDA Enzyme Link: | BRENDA 6.3.4.14 |
| KEGG Enzyme Link: | KEGG6.3.4.14 |
| BioCyc Enzyme Link: | BioCyc 6.3.4.14 |
| ExPASy Enzyme Link: | ExPASy6.3.4.14 |
| EC2PDB Enzyme Link: | EC2PDB 6.3.4.14 |
| ExplorEnz Enzyme Link: | ExplorEnz 6.3.4.14 |
| PRIAM enzyme-specific profiles Link: | PRIAM 6.3.4.14 |
| IntEnz Enzyme Link: | IntEnz 6.3.4.14 |
| MEDLINE Enzyme Link: | MEDLINE 6.3.4.14 |
| RHEA:13501 | ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate |
| RULE(radius=1) | [*:1]-[NH;+0:2]-[*:3].[*:4]=[C;H0;+0:5](-[*:6])-[OH;+0:7].[*:8]=[P;H0;+0:9](-[*:10])(-[*:11])-[O;H0;+0:12]-[*:13]>>[*:1]-[N;H0;+0:2](-[*:3])-[C;H0;+0:5](=[*:4])-[*:6].[*:13]-[OH;+0:12].[*:8]=[P;H0;+0:9](-[*:10])(-[*:11])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Biochemical and molecular biological characterization of CAC2, the Arabidopsis thaliana gene coding for the biotin carboxylase subunit of the plastidic acetyl-coenzyme A carboxylase. | Sun J, Ke J, Johnson JL, Nikolau BJ, Wurtele ES | 1997 Dec | 9414551 |
| Enzymatic carboxylation of biotin: molecular and catalytic properties of a component enzyme of acetyl CoA carboxylase. | Dimroth P, Guchhait RB, Stoll E, Lane MD | 1970 Nov | 4922289 |
| Crystal structure of Spot 14, a modulator of fatty acid synthesis. | Colbert CL, Kim CW, Moon YA, Henry L, Palnitkar M, McKean WB, Fitzgerald K, Deisenhofer J, Horton JD, Kwon HJ | 2010 Nov 2 | 20952656 |
| Propionyl coenzyme A (propionyl-CoA) carboxylase in Haloferax mediterranei: Indispensability for propionyl-CoA assimilation and impacts on global metabolism. | Hou J, Xiang H, Han J | 2015 Jan | 25398867 |