EC number:6.3.4.17

Enzyme

Download
EC Tree
     6. Ligases
        6.3 Forming carbon-nitrogen bonds
            6.3.4 Other carbon-nitrogen ligases
ID:6.3.4.17
Description:Formate--dihydrofolate ligase.
Alternative Name: Formyl dihydrofolate synthase.
Dihydrofolate formyltransferase.

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.
PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.3.4.17
BRENDA Enzyme Link: BRENDA 6.3.4.17
KEGG Enzyme Link: KEGG6.3.4.17
BioCyc Enzyme Link: BioCyc 6.3.4.17
ExPASy Enzyme Link: ExPASy6.3.4.17
EC2PDB Enzyme Link: EC2PDB 6.3.4.17
ExplorEnz Enzyme Link: ExplorEnz 6.3.4.17
PRIAM enzyme-specific profiles Link: PRIAM 6.3.4.17
IntEnz Enzyme Link: IntEnz 6.3.4.17
MEDLINE Enzyme Link: MEDLINE 6.3.4.17

EC number:6.3.4.17

MSA:

6.3.4.17;
Phylogenetic Tree:

6.3.4.17;
Uniprot:
M-CSA:
RHEA:24328 7,8-dihydrofolate + ATP + formate = 10-formyldihydrofolate + ADP + phosphate
RULE(radius=1) [*:1]-[NH;+0:2]-[*:3].[*:4]=[CH;+0:5]-[OH;+0:6].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[O;H0;+0:11]-[*:12]>>[*:1]-[N;H0;+0:2](-[*:3])-[CH;+0:5]=[*:4].[*:12]-[OH;+0:11].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[OH;+0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Isolation and characterization of a novel dihydrofolate formylating enzyme from human MCF-7 breast cancer cells.Drake JC, Baram J, Allegra CJ1990 Feb 12306274