EC number:6.3.4.18
Enzyme
Download| EC Tree |
| 6. Ligases |
| 6.3 Forming carbon-nitrogen bonds |
| 6.3.4 Other carbon-nitrogen ligases |
| ID: | 6.3.4.18 |
|---|---|
| Description: | 5-(carboxyamino)imidazole ribonucleotide synthase. |
| Alternative Name: |
N(5)-carboxyaminoimidazole ribonucleotide synthetase. N(5)-CAIR synthetase. |
| Cath: | 3.30.1490.20; 3.30.470.20; 3.40.50.7700; 3.40.50.20; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 6.3.4.18 |
| BRENDA Enzyme Link: | BRENDA 6.3.4.18 |
| KEGG Enzyme Link: | KEGG6.3.4.18 |
| BioCyc Enzyme Link: | BioCyc 6.3.4.18 |
| ExPASy Enzyme Link: | ExPASy6.3.4.18 |
| EC2PDB Enzyme Link: | EC2PDB 6.3.4.18 |
| ExplorEnz Enzyme Link: | ExplorEnz 6.3.4.18 |
| PRIAM enzyme-specific profiles Link: | PRIAM 6.3.4.18 |
| IntEnz Enzyme Link: | IntEnz 6.3.4.18 |
| MEDLINE Enzyme Link: | MEDLINE 6.3.4.18 |
| RHEA:19317 | 5-amino-1-(5-phospho-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[OH;+0:6].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[O;H0;+0:11]-[*:12]>>[*:1]-[NH;+0:2]-[C;H0;+0:4](=[*:3])-[*:5].[*:12]-[OH;+0:11].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and characterization of the purE, purK, and purC gene products: identification of a previously unrecognized energy requirement in the purine biosynthetic pathway. | Meyer E, Leonard NJ, Bhat B, Stubbe J, Smith JM | 1992 Jun 2 | 1534690 |
| N5-carboxyaminoimidazole ribonucleotide: evidence for a new intermediate and two new enzymatic activities in the de novo purine biosynthetic pathway of Escherichia coli. | Mueller EJ, Meyer E, Rudolph J, Davisson VJ, Stubbe J | 1994 Mar 1 | 8117684 |
| Three-dimensional structure of N5-carboxyaminoimidazole ribonucleotide synthetase: a member of the ATP grasp protein superfamily. | Thoden JB, Kappock TJ, Stubbe J, Holden HM | 1999 Nov 23 | 10569930 |