EC number:6.3.4.19
Enzyme
Download| EC Tree |
| 6. Ligases |
| 6.3 Forming carbon-nitrogen bonds |
| 6.3.4 Other carbon-nitrogen ligases |
| ID: | 6.3.4.19 |
|---|---|
| Description: | tRNA(Ile)-lysidine synthetase. |
| Alternative Name: |
Isoleucine-specific transfer ribonucleate lysidine synthetase. |
| Cath: | 1.10.10.1360; 3.30.70.2200; 3.40.50.620; 3.90.600.20; 1.20.59.20; 1.20.59.30; 2.40.50.1010; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 6.3.4.19 |
| BRENDA Enzyme Link: | BRENDA 6.3.4.19 |
| KEGG Enzyme Link: | KEGG6.3.4.19 |
| BioCyc Enzyme Link: | BioCyc 6.3.4.19 |
| ExPASy Enzyme Link: | ExPASy6.3.4.19 |
| EC2PDB Enzyme Link: | EC2PDB 6.3.4.19 |
| ExplorEnz Enzyme Link: | ExplorEnz 6.3.4.19 |
| PRIAM enzyme-specific profiles Link: | PRIAM 6.3.4.19 |
| IntEnz Enzyme Link: | IntEnz 6.3.4.19 |
| MEDLINE Enzyme Link: | MEDLINE 6.3.4.19 |
| RHEA:43744 | ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2) |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]-[O;H0;+0:4]-[P;H0;+0:5](-[*:6])(=[*:7])-[*:8].[*:9]:[c;H0;+0:10](=[O;H0;+0:11]):[*:12]:[c;H0;+0:13](:[*:14])-[NH2;+0:15]>>[*:3]-[OH;+0:4].[*:6]-[P;H0;+0:5](=[*:7])(-[*:8])-[OH;+0:11].[*:9]:[c;H0;+0:10](:[*:12]:[c;H0;+0:13](:[*:14])=[NH;+0:15])-[NH;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural basis for translational fidelity ensured by transfer RNA lysidine synthetase. | Nakanishi K, Bonnefond L, Kimura S, Suzuki T, Ishitani R, Nureki O | 2009 Oct 22 | 19847269 |
| molecular mechanism of lysidine synthesis that determines tRNA identity and codon recognition. | Ikeuchi Y, Soma A, Ote T, Kato J, Sekine Y, Suzuki T | 2005 Jul 22 | 16039592 |
| Structural basis for lysidine formation by ATP pyrophosphatase accompanied by a lysine-specific loop and a tRNA-recognition domain. | Nakanishi K, Fukai S, Ikeuchi Y, Soma A, Sekine Y, Suzuki T, Nureki O | 2005 May 24 | 15894617 |
| An RNA-modifying enzyme that governs both the codon and amino acid specificities of isoleucine tRNA. | Soma A, Ikeuchi Y, Kanemasa S, Kobayashi K, Ogasawara N, Ote T, Kato J, Watanabe K, Sekine Y, Suzuki T | 2003 Sep | 14527414 |