EC number:6.3.4.2

Enzyme

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     6. Ligases
        6.3 Forming carbon-nitrogen bonds
            6.3.4 Other carbon-nitrogen ligases
ID:6.3.4.2
Description:CTP synthase (glutamine hydrolyzing).
Alternative Name: UTP--ammonia ligase.
CTP synthetase.
Prosite: PDOC00405;
PDB:
PDBScop
2VKT 8089725; 8089727;
2V4U 8089725; 8089727;
3NVA 8089720; 8089721; 8089722; 8089723; 8089720; 8089721; 8089722; 8089723;
1VCO 8089716; 8089717; 8089718; 8089719;
1VCN 8089716; 8089717; 8089718; 8089719;
 » show all
Cath: 3.40.50.880; 3.40.50.300;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.3.4.2
BRENDA Enzyme Link: BRENDA 6.3.4.2
KEGG Enzyme Link: KEGG6.3.4.2
BioCyc Enzyme Link: BioCyc 6.3.4.2
ExPASy Enzyme Link: ExPASy6.3.4.2
EC2PDB Enzyme Link: EC2PDB 6.3.4.2
ExplorEnz Enzyme Link: ExplorEnz 6.3.4.2
PRIAM enzyme-specific profiles Link: PRIAM 6.3.4.2
IntEnz Enzyme Link: IntEnz 6.3.4.2
MEDLINE Enzyme Link: MEDLINE 6.3.4.2

EC number:6.3.4.2

MSA:

6.3.4.2;
Phylogenetic Tree:

6.3.4.2;
Uniprot:
M-CSA:
RHEA:26426 ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate
RULE(radius=1) [*:1]-[C;H0;+0:2](=[*:3])-[NH2;+0:4].[*:5]:[c;H0;+0:6](=[O;H0;+0:7]):[nH;+0:8]:[*:9].[*:10]=[P;H0;+0:11](-[*:12])(-[*:13])-[O;H0;+0:14]-[*:15].[OH2;+0:16]>>[*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:7].[*:15]-[OH;+0:14].[*:5]:[c;H0;+0:6](-[NH2;+0:4]):[n;H0;+0:8]:[*:9].[*:10]=[P;H0;+0:11](-[*:12])(-[*:13])-[OH;+0:16]
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References

TitleAuthorsDatePubMed ID
Ligand-induced dimer-to-tetramer transformation in cytosine triphosphate synthetase.Levitzki A, Koshland DE Jr1972 Jan 184550560
Mechanistic investigations of Escherichia coli cytidine-5'-triphosphate synthetase. Detection of an intermediate by positional isotope exchange experiments.von der Saal W, Anderson PM, Villafranca JJ1985 Dec 52933396
Investigation of the mechanism of CTP synthetase using rapid quench and isotope partitioning methods.Lewis DA, Villafranca JJ1989 Oct 172532543
Enzymatic amination of uridine triphosphate to cytidine triphosphate.LIEBERMAN I1956 Oct13367044
Cloning and verification of the Lactococcus lactis pyrG gene and characterization of the gene product, CTP synthase.Wadskov-Hansen SL, Willemoës M, Martinussen J, Hammer K, Neuhard J, Larsen S2001 Oct 1211500486