EC number:6.3.4.20

Enzyme

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EC Tree
     6. Ligases
        6.3 Forming carbon-nitrogen bonds
            6.3.4 Other carbon-nitrogen ligases
ID:6.3.4.20
Description:7-cyano-7-deazaguanine synthase.
Alternative Name: PreQ0 synthase.
7-cyano-7-carbaguanine synthase.
Cath: 3.40.50.620;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.3.4.20
BRENDA Enzyme Link: BRENDA 6.3.4.20
KEGG Enzyme Link: KEGG6.3.4.20
BioCyc Enzyme Link: BioCyc 6.3.4.20
ExPASy Enzyme Link: ExPASy6.3.4.20
EC2PDB Enzyme Link: EC2PDB 6.3.4.20
ExplorEnz Enzyme Link: ExplorEnz 6.3.4.20
PRIAM enzyme-specific profiles Link: PRIAM 6.3.4.20
IntEnz Enzyme Link: IntEnz 6.3.4.20
MEDLINE Enzyme Link: MEDLINE 6.3.4.20

EC number:6.3.4.20

MSA:

6.3.4.20;
Phylogenetic Tree:

6.3.4.20;
Uniprot:
M-CSA:
RHEA:27982 7-carboxy-7-deazaguanine + ATP + NH4(+) = 7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate
RULE(radius=1) [*:1]-[C;H0;+0:2](=[O;H0;+0:3])-[OH;+0:4].[*:5]=[P;H0;+0:6](-[*:7])(-[*:8])-[O;H0;+0:9]-[*:10].[NH3;+0:11]>>[*:1]-[C;H0;+0:2]#[N;H0;+0:11].[*:10]-[OH;+0:9].[*:5]=[P;H0;+0:6](-[*:7])(-[*:8])-[OH;+0:4].[OH2;+0:3]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
The deazapurine biosynthetic pathway revealed: in vitro enzymatic synthesis of PreQ(0) from guanosine 5'-triphosphate in four steps.McCarty RM, Somogyi A, Lin G, Jacobsen NE, Bandarian V2009 May 1219354300