EC number:6.3.4.22
Enzyme
Download| EC Tree |
| 6. Ligases |
| 6.3 Forming carbon-nitrogen bonds |
| 6.3.4 Other carbon-nitrogen ligases |
| ID: | 6.3.4.22 |
|---|---|
| Description: | tRNA(Ile)(2)-agmatinylcytidine synthase. |
| Alternative Name: |
tRNA(Ile)-agmatidine synthetase. tRNA(Ile)-agm(2)C synthetase. tRNA(Ile)-2-agmatinylcytidine synthetase. |
| Cath: | 3.30.70.2200; 3.90.600.20; 2.40.50.1010; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 6.3.4.22 |
| BRENDA Enzyme Link: | BRENDA 6.3.4.22 |
| KEGG Enzyme Link: | KEGG6.3.4.22 |
| BioCyc Enzyme Link: | BioCyc 6.3.4.22 |
| ExPASy Enzyme Link: | ExPASy6.3.4.22 |
| EC2PDB Enzyme Link: | EC2PDB 6.3.4.22 |
| ExplorEnz Enzyme Link: | ExplorEnz 6.3.4.22 |
| PRIAM enzyme-specific profiles Link: | PRIAM 6.3.4.22 |
| IntEnz Enzyme Link: | IntEnz 6.3.4.22 |
| MEDLINE Enzyme Link: | MEDLINE 6.3.4.22 |
| RHEA:43608 | agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O = 2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]:[c;H0;+0:4](=[O;H0;+0:5]):[*:6]:[c;H0;+0:7](:[*:8])-[NH2;+0:9].[*:10]=[P;H0;+0:11](-[*:12])(-[*:13])-[O;H0;+0:14]-[*:15]-[O;H0;+0:16]-[P;H0;+0:17](=[*:18])(-[*:19])-[*:20].[OH2;+0:21]>>[*:3]:[c;H0;+0:4](:[*:6]:[c;H0;+0:7](:[*:8])=[NH;+0:9])-[NH;+0:2]-[*:1].[*:10]=[P;H0;+0:11](-[*:12])(-[*:13])-[OH;+0:5].[*:18]=[P;H0;+0:17](-[*:19])(-[*:20])-[OH;+0:21].[OH;+0:16]-[*:15]-[OH;+0:14] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Crystallization and preliminary X-ray diffraction analysis of an archaeal tRNA-modification enzyme, TiaS, complexed with tRNA(Ile2) and ATP. | Osawa T, Inanaga H, Kimura S, Terasaka N, Suzuki T, Numata T | 2011 Nov 1 | 22102245 |
| Agmatine-conjugated cytidine in a tRNA anticodon is essential for AUA decoding in archaea. | Ikeuchi Y, Kimura S, Numata T, Nakamura D, Yokogawa T, Ogata T, Wada T, Suzuki T, Suzuki T | 2010 Apr | 20139989 |
| Tricuspid valve infective endocarditis and pulmonary sepsis due to Erysipelothrix rhusiopathiae successfully treated with high doses of ciprofloxacin but complicated by gynaecomastia. | MacGowan AP, Reeves DS, Wright C, Glover SC | 1991 Jan | 2002222 |