EC number:6.3.4.23

Enzyme

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     6. Ligases
        6.3 Forming carbon-nitrogen bonds
            6.3.4 Other carbon-nitrogen ligases
ID:6.3.4.23
Description:Formate--phosphoribosylaminoimidazolecarboxamide ligase.
Alternative Name: 5'-monophosphate synthetase.
5-formaminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl
5-formaminoimidazole-4-carboxamide ribonucleotide synthetase.
Cath: 3.30.1490.20; 3.30.470.20; 3.40.50.20;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.3.4.23
BRENDA Enzyme Link: BRENDA 6.3.4.23
KEGG Enzyme Link: KEGG6.3.4.23
BioCyc Enzyme Link: BioCyc 6.3.4.23
ExPASy Enzyme Link: ExPASy6.3.4.23
EC2PDB Enzyme Link: EC2PDB 6.3.4.23
ExplorEnz Enzyme Link: ExplorEnz 6.3.4.23
PRIAM enzyme-specific profiles Link: PRIAM 6.3.4.23
IntEnz Enzyme Link: IntEnz 6.3.4.23
MEDLINE Enzyme Link: MEDLINE 6.3.4.23

EC number:6.3.4.23

MSA:

6.3.4.23;
Phylogenetic Tree:

6.3.4.23;
Uniprot:
M-CSA:
RHEA:24836 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + ATP + formate = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate
RULE(radius=1) [*:1]-[NH2;+0:2].[*:3]=[CH;+0:4]-[OH;+0:5].[*:6]=[P;H0;+0:7](-[*:8])(-[*:9])-[O;H0;+0:10]-[*:11]>>[*:1]-[NH;+0:2]-[CH;+0:4]=[*:3].[*:11]-[OH;+0:10].[*:6]=[P;H0;+0:7](-[*:8])(-[*:9])-[OH;+0:5]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
A Methanocaldococcus jannaschii archaeal signature gene encodes for a 5-formaminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate synthetase. A new enzyme in purine biosynthesis.Ownby K, Xu H, White RH2005 Mar 2515623504