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6. Ligases

6.3 Forming carbon-nitrogen bonds

6.3.4 Other carbon-nitrogen ligases

ID:

6.3.4.3

Description:

Formate--tetrahydrofolate ligase.

Alternative Name:

Tetrahydrofolic formylase.
Tetrahydrofolate formylase.
Formyltetrahydrofolate synthetase.

Prosite:

PDOC00595;

PDB:

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Cath:

1.10.8.770; 3.30.1510.10; 3.40.50.720; 3.40.50.10860; 3.40.50.300; 3.10.410.10;

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PDB	Click once to unfold,double click to fold. 3DO6; 3QUS; 1FPM; 1FP7; 1EG7; 4JKI; 4JJZ; 4JJK; 4JIM; 4IOM; 4IOL; 4IOK; 4IOJ;

UniProtKB Enzyme Link:	UniProtKB 6.3.4.3
BRENDA Enzyme Link:	BRENDA 6.3.4.3
KEGG Enzyme Link:	KEGG6.3.4.3
BioCyc Enzyme Link:	BioCyc 6.3.4.3
ExPASy Enzyme Link:	ExPASy6.3.4.3
EC2PDB Enzyme Link:	EC2PDB 6.3.4.3
ExplorEnz Enzyme Link:	ExplorEnz 6.3.4.3
PRIAM enzyme-specific profiles Link:	PRIAM 6.3.4.3
IntEnz Enzyme Link:	IntEnz 6.3.4.3
MEDLINE Enzyme Link:	MEDLINE 6.3.4.3

RHEA:20221	(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6S)-10-formyltetrahydrofolate + ADP + phosphate
RULE(radius=1)	[:1]-[NH;+0:2]-[:3].[:4]=[CH;+0:5]-[OH;+0:6].[:7]=[P;H0;+0:8](-[:9])(-[:10])-[O;H0;+0:11]-[:12]>>[:1]-[N;H0;+0:2](-[:3])-[CH;+0:5]=[:4].[:12]-[OH;+0:11].[:7]=[P;H0;+0:8](-[:9])(-[:10])-[OH;+0:6]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Formyltetrahydrofolate synthetase. I. Isolation and crystallization of the enzyme.	RABINOWITZ JC, PRICER WE Jr	1962 Sep	14489619
[Research on monocarbon compounds. I. The tetrahydrofolate formylase from pigeon liver. Purification and mechanism].	JAENICKE L, BRODE E	1961	13789141
Purification and properties of the formate-activating enzyme from Micrococcus aerogenes.	WHITELEY HR, OSBORN MJ, HUENNEKENS FM	1959 Jun	13654413