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6. Ligases

6.3 Forming carbon-nitrogen bonds

6.3.4 Other carbon-nitrogen ligases

ID:

6.3.4.4

Description:

Adenylosuccinate synthase.

Alternative Name:

Succinoadenylic kinosynthetase.
IMP--aspartate ligase.
Adenylosuccinate synthetase.

Prosite:

PDOC00444;

PDB:

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Cath:

1.10.300.10; 3.90.170.10; 3.40.440.10;

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PDB	Click once to unfold,double click to fold. 5K7X; 2D7U; 1LNY; 1IWE; 2DGN; 1MF1; 1MF0; 1MEZ; 1LOO; 1LON; 1J4B; 2V40; 1DJ3; 3R7T; 3HID; 1P9B; 3UE9; 1DJ2; 1HOP; 1HOO; 1HON; 1ADI; 1ADE; 2GCQ; 1SOO; 1SON; 1QF5; 1QF4; 1NHT; 1KSZ; 1KKB; 1KJX; 1JUY; 1GIN; 1GIM; 1CIB; 1CH8; 1CG4; 1CG3; 1CG1; 1CG0; 6C25; 6BS7; 4M9D; 4M0G; 1KKF;

UniProtKB Enzyme Link:	UniProtKB 6.3.4.4
BRENDA Enzyme Link:	BRENDA 6.3.4.4
KEGG Enzyme Link:	KEGG6.3.4.4
BioCyc Enzyme Link:	BioCyc 6.3.4.4
ExPASy Enzyme Link:	ExPASy6.3.4.4
EC2PDB Enzyme Link:	EC2PDB 6.3.4.4
ExplorEnz Enzyme Link:	ExplorEnz 6.3.4.4
PRIAM enzyme-specific profiles Link:	PRIAM 6.3.4.4
IntEnz Enzyme Link:	IntEnz 6.3.4.4
MEDLINE Enzyme Link:	MEDLINE 6.3.4.4

RHEA:15753	GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate
RULE(radius=1)	[:1]-[NH2;+0:2].[:3]-[O;H0;+0:4]-[P;H0;+0:5](=[:6])(-[:7])-[:8].[:9]:[nH;+0:10]:[c;H0;+0:11](:[:12])=[O;H0;+0:13]>>[:3]-[OH;+0:4].[:9]:[n;H0;+0:10]:[c;H0;+0:11](:[:12])-[NH;+0:2]-[:1].[:6]=[P;H0;+0:5](-[:7])(-[:8])-[OH;+0:13]
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Title	Authors	Date	PubMed ID
Relationship of conserved residues in the IMP binding site to substrate recognition and catalysis in Escherichia coli adenylosuccinate synthetase.	Wang W, Hou Z, Honzatko RB, Fromm HJ	1997 Jul 4	9202000
Entrapment of 6-thiophosphoryl-IMP in the active site of crystalline adenylosuccinate synthetase from Escherichia coli.	Poland BW, Bruns C, Fromm HJ, Honzatko RB	1997 Jun 13	9182542
Residues essential for catalysis and stability of the active site of Escherichia coli adenylosuccinate synthetase as revealed by directed mutation and kinetics.	Kang C, Sun N, Poland BW, Gorrell A, Honzatko RB, Fromm HJ	1997 May 2	9115248
Studies of ligand binding to Escherichia coli adenylosuccinate synthetase.	Soans C, Fromm HJ	1991 Nov 15	1929424
Mechanistic implications from crystalline complexes of wild-type and mutant adenylosuccinate synthetases from Escherichia coli.	Choe JY, Poland BW, Fromm HJ, Honzatko RB	1999 May 25	10346917