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6. Ligases

6.3 Forming carbon-nitrogen bonds

6.3.4 Other carbon-nitrogen ligases

ID:

6.3.4.5

Description:

Argininosuccinate synthase.

Alternative Name:

Citrulline--aspartate ligase.
Argininosuccinate synthetase.
Arginine succinate synthetase.

Prosite:

PDOC00488;

PDB:

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Cath:

1.10.287.40; 1.10.287.400; 1.20.5.470; 3.40.50.620; 3.90.1260.10;

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PDB	Click once to unfold,double click to fold. 1VL2; 1KP3; 1KP2; 1K97; 1K92; 1KOR; 1KH3; 1KH2; 1KH1; 1J21; 1J20; 1J1Z; 6E5Y; 5US8; 4NZP; 2NZ2;

UniProtKB Enzyme Link:	UniProtKB 6.3.4.5
BRENDA Enzyme Link:	BRENDA 6.3.4.5
KEGG Enzyme Link:	KEGG6.3.4.5
BioCyc Enzyme Link:	BioCyc 6.3.4.5
ExPASy Enzyme Link:	ExPASy6.3.4.5
EC2PDB Enzyme Link:	EC2PDB 6.3.4.5
ExplorEnz Enzyme Link:	ExplorEnz 6.3.4.5
PRIAM enzyme-specific profiles Link:	PRIAM 6.3.4.5
IntEnz Enzyme Link:	IntEnz 6.3.4.5
MEDLINE Enzyme Link:	MEDLINE 6.3.4.5

RHEA:10932	ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)
RULE(radius=1)	[:1]-[C;H0;+0:2](-[NH2;+0:3])=[O;H0;+0:4].[:5]-[NH2;+0:6].[:7]-[O;H0;+0:8]-[P;H0;+0:9](-[:10])(=[:11])-[:12]>>[:1]-[C;H0;+0:2](=[NH;+0:3])-[NH;+0:6]-[:5].[:7]-[OH;+0:8].[:10]-[P;H0;+0:9](=[:11])(-[:12])-[OH;+0:4]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Characterization of human wild-type and mutant argininosuccinate synthetase proteins expressed in bacterial cells.	Shaheen N, Kobayashi K, Terazono H, Fukushige T, Horiuchi M, Saheki T	1994-1995	8792870
Measurement of positional isotope exchange rates in enzyme-catalyzed reactions by fast atom bombardment mass spectrometry: application to argininosuccinate synthetase.	Hilscher LW, Hanson CD, Russell DH, Raushel FM	1985 Oct 8	2867775
Kinetic mutations in argininosuccinate synthetase deficiency: characterisation and in vitro correction by substrate supplementation.	Diez-Fernandez C, Wellauer O, Gemperle C, Rüfenacht V, Fingerhut R, Häberle J	2016 Oct	27287393
Structure of human argininosuccinate synthetase.	Karlberg T, Collins R, van den Berg S, Flores A, Hammarström M, Högbom M, Holmberg Schiavone L, Uppenberg J	2008 Mar	18323623
Almost all about citrulline in mammals.	Curis E, Nicolis I, Moinard C, Osowska S, Zerrouk N, Bénazeth S, Cynober L	2005 Nov	16082501
Structures of argininosuccinate synthetase in enzyme-ATP substrates and enzyme-AMP product forms: stereochemistry of the catalytic reaction.	Goto M, Omi R, Miyahara I, Sugahara M, Hirotsu K	2003 Jun 20	12684518
The 1.6 A crystal structure of E. coli argininosuccinate synthetase suggests a conformational change during catalysis.	Lemke CT, Howell PL	2001 Dec	11738042