EC number:6.3.4.9
Enzyme
Download| EC Tree |
| 6. Ligases |
| 6.3 Forming carbon-nitrogen bonds |
| 6.3.4 Other carbon-nitrogen ligases |
| ID: | 6.3.4.9 |
|---|---|
| Description: | Biotin--[methylmalonyl-CoA-carboxytransferase] ligase. |
| Alternative Name: |
Biotin-transcarboxylase synthetase. Biotin--[methylmalonyl-CoA-carboxytransferase] synthetase. Biotin--[methylmalonyl-CoA-carboxyltransferase] synthetase. Biotin--[methylmalonyl-CoA-carboxyltransferase] ligase. |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 6.3.4.9 |
| BRENDA Enzyme Link: | BRENDA 6.3.4.9 |
| KEGG Enzyme Link: | KEGG6.3.4.9 |
| BioCyc Enzyme Link: | BioCyc 6.3.4.9 |
| ExPASy Enzyme Link: | ExPASy6.3.4.9 |
| EC2PDB Enzyme Link: | EC2PDB 6.3.4.9 |
| ExplorEnz Enzyme Link: | ExplorEnz 6.3.4.9 |
| PRIAM enzyme-specific profiles Link: | PRIAM 6.3.4.9 |
| IntEnz Enzyme Link: | IntEnz 6.3.4.9 |
| MEDLINE Enzyme Link: | MEDLINE 6.3.4.9 |
| RHEA:23668 | apo-[methylmalonyl-CoA:pyruvate carboxytransferase] + ATP + biotin = AMP + diphosphate + H(+) + holo-[methylmalonyl-CoA:pyruvate carboxytransferase] |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:4].[*:5]-[NH2;+0:6].[*:7]-[O;H0;+0:8]-[P;H0;+0:9](-[*:10])(=[*:11])-[*:12]>>[*:1]-[C;H0;+0:2](=[*:3])-[NH;+0:6]-[*:5].[*:7]-[OH;+0:8].[*:10]-[P;H0;+0:9](=[*:11])(-[*:12])-[OH;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Selectivity in post-translational biotin addition to five human carboxylases. | Ingaramo M, Beckett D | 2012 Jan 13 | 22123817 |
| THE ENZYMATIC SYNTHESIS OF HOLOTRANSCARBOXYLASE FROM APOTRANSCARBOXYLASE AND (+)-BIOTIN. I. PURIFICATION OF THE APOENZYME AND SYNTHETASE; CHARACTERISTICS OF THE REACTION. | LANE MD, YOUNG DL, LYNEN F | 1964 Sep | 14216436 |
| The enzymatic biotinylation of proteins: a post-translational modification of exceptional specificity. | Chapman-Smith A, Cronan JE Jr | 1999 Sep | 10470036 |