EC number:6.3.5.1

Enzyme

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     6. Ligases
        6.3 Forming carbon-nitrogen bonds
            6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor
ID:6.3.5.1
Description:NAD(+) synthase (glutamine-hydrolyzing).
Alternative Name: Nicotinamide adenine dinucleotide synthetase (glutamine).
NAD(+) synthetase (glutamine-hydrolyzing).
Prosite: PDOC50263;
PDB:
PDBScop
Cath: 1.10.10.1140; 3.40.50.620; 3.60.110.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.3.5.1
BRENDA Enzyme Link: BRENDA 6.3.5.1
KEGG Enzyme Link: KEGG6.3.5.1
BioCyc Enzyme Link: BioCyc 6.3.5.1
ExPASy Enzyme Link: ExPASy6.3.5.1
EC2PDB Enzyme Link: EC2PDB 6.3.5.1
ExplorEnz Enzyme Link: ExplorEnz 6.3.5.1
PRIAM enzyme-specific profiles Link: PRIAM 6.3.5.1
IntEnz Enzyme Link: IntEnz 6.3.5.1
MEDLINE Enzyme Link: MEDLINE 6.3.5.1

EC number:6.3.5.1

MSA:

6.3.5.1;
Phylogenetic Tree:

6.3.5.1;
Uniprot:
M-CSA:
RHEA:24384 ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate + H(+) + L-glutamate + NAD(+)
RULE(radius=1) [*:1]-[C;H0;+0:2](=[*:3])-[NH2;+0:4].[*:5]-[P;H0;+0:6](=[*:7])(-[*:8])-[O;H0;+0:9]-[*:10].[*:11]=[C;H0;+0:12](-[*:13])-[OH;+0:14].[OH2;+0:15]>>[*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:14].[*:10]-[OH;+0:9].[*:5]-[P;H0;+0:6](=[*:7])(-[*:8])-[OH;+0:15].[*:11]=[C;H0;+0:12](-[*:13])-[NH2;+0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Regulation of the intersubunit ammonia tunnel in Mycobacterium tuberculosis glutamine-dependent NAD+ synthetase.Chuenchor W, Doukov TI, Resto M, Chang A, Gerratana B2012 Apr 1522280445
Regulation of active site coupling in glutamine-dependent NAD(+) synthetase.LaRonde-LeBlanc N, Resto M, Gerratana B2009 Apr19270703
Molecular identification of human glutamine- and ammonia-dependent NAD synthetases. Carbon-nitrogen hydrolase domain confers glutamine dependency.Hara N, Yamada K, Terashima M, Osago H, Shimoyama M, Tsuchiya M2003 Mar 2812547821