EC number:6.3.5.10

Enzyme

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     6. Ligases
        6.3 Forming carbon-nitrogen bonds
            6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor
ID:6.3.5.10
Description:Adenosylcobyric acid synthase (glutamine-hydrolyzing).
Alternative Name: Cobyric acid synthase.
Ado-cobyric acid synthase (glutamine hydrolyzing).
5'-deoxy-5'-adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.3.5.10
BRENDA Enzyme Link: BRENDA 6.3.5.10
KEGG Enzyme Link: KEGG6.3.5.10
BioCyc Enzyme Link: BioCyc 6.3.5.10
ExPASy Enzyme Link: ExPASy6.3.5.10
EC2PDB Enzyme Link: EC2PDB 6.3.5.10
ExplorEnz Enzyme Link: ExplorEnz 6.3.5.10
PRIAM enzyme-specific profiles Link: PRIAM 6.3.5.10
IntEnz Enzyme Link: IntEnz 6.3.5.10
MEDLINE Enzyme Link: MEDLINE 6.3.5.10

EC number:6.3.5.10

MSA:

6.3.5.10;
Phylogenetic Tree:

6.3.5.10;
Uniprot:
M-CSA:
RHEA:23256 adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O + 4 L-glutamine = adenosylcob(III)yrate + 4 ADP + 4 H(+) + 4 L-glutamate + 4 phosphate
RULE(radius=1)
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Biosynthesis of vitamin B12: stepwise amidation of carboxyl groups b, d, e, and g of cobyrinic acid a,c-diamide is catalyzed by one enzyme in Pseudomonas denitrificans.Blanche F, Couder M, Debussche L, Thibaut D, Cameron B, Crouzet J1991 Oct1917839
The biosynthesis of adenosylcobalamin (vitamin B12).Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC2002 Aug12195810