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6. Ligases

6.3 Forming carbon-nitrogen bonds

6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor

ID:

6.3.5.2

Description:

GMP synthase (glutamine-hydrolyzing).

Alternative Name:

GMP synthetase (glutamine-hydrolyzing).

Prosite:

PDOC00405;

PDB:

PDB	Scop

Cath:

3.30.300.10; 3.40.50.620; 3.40.50.880;

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UniProtKB Enzyme Link:	UniProtKB 6.3.5.2
BRENDA Enzyme Link:	BRENDA 6.3.5.2
KEGG Enzyme Link:	KEGG6.3.5.2
BioCyc Enzyme Link:	BioCyc 6.3.5.2
ExPASy Enzyme Link:	ExPASy6.3.5.2
EC2PDB Enzyme Link:	EC2PDB 6.3.5.2
ExplorEnz Enzyme Link:	ExplorEnz 6.3.5.2
PRIAM enzyme-specific profiles Link:	PRIAM 6.3.5.2
IntEnz Enzyme Link:	IntEnz 6.3.5.2
MEDLINE Enzyme Link:	MEDLINE 6.3.5.2

RHEA:11680	ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate
RULE(radius=1)	[:1]-[C;H0;+0:2](=[:3])-[NH2;+0:4].[:5]-[O;H0;+0:6]-[P;H0;+0:7](-[:8])(=[:9])-[:10].[:11]:[c;H0;+0:12](=[O;H0;+0:13]):[nH;+0:14]:[:15].[OH2;+0:16]>>[:1]-[C;H0;+0:2](=[:3])-[OH;+0:13].[:5]-[OH;+0:6].[:8]-[P;H0;+0:7](=[:9])(-[:10])-[OH;+0:16].[:11]:[c;H0;+0:12](-[NH2;+0:4]):[n;H0;+0:14]:[:15]
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Core-to-Core	More

Title	Authors	Date	PubMed ID
Identification of a trpG-related glutamine amide transfer domain in Escherichia coli GMP synthetase.	Zalkin H, Argos P, Narayana SV, Tiedeman AA, Smith JM	1985 Mar 25	2982857
The effects of removing the GAT domain from E. coli GMP synthetase.	Abbott JL, Newell JM, Lightcap CM, Olanich ME, Loughlin DT, Weller MA, Lam G, Pollack S, Patton WA	2006 Dec	17103135
Biosynthesis of guanosine 5'-phosphate. II. Amination of xanthosine 5'-phosphate by purified enzyme from pigeon liver.	LAGERKVIST U	1958 Jul	13563458