EC number:6.3.5.5
Enzyme
Download| EC Tree |
| 6. Ligases |
| 6.3 Forming carbon-nitrogen bonds |
| 6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor |
| ID: | 6.3.5.5 | ||
|---|---|---|---|
| Description: | Carbamoyl-phosphate synthase (glutamine-hydrolyzing). | ||
| Alternative Name: |
Glutamine-dependent carbamyl phosphate synthetase. Glutamine-dependent carbamoyl-phosphate synthase. GD-CPSase. CPS. Carbamyl phosphate synthetase (glutamine). Carbamoylphosphate synthetase II. Carbamoyl-phosphate synthetase (glutamine-hydrolyzing). Carbamoyl phosphate synthetase. | ||
| Prosite: | PDOC50975; PDOC00676; PDOC00405; | ||
| PDB: |
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| Cath: | 1.10.1030.10; 3.20.20.140; 3.30.1490.20; 3.30.470.20; 3.40.50.880; 3.50.30.20; 3.40.50.1370; 3.40.50.1380; 3.40.50.20; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 6.3.5.5 |
| BRENDA Enzyme Link: | BRENDA 6.3.5.5 |
| KEGG Enzyme Link: | KEGG6.3.5.5 |
| BioCyc Enzyme Link: | BioCyc 6.3.5.5 |
| ExPASy Enzyme Link: | ExPASy6.3.5.5 |
| EC2PDB Enzyme Link: | EC2PDB 6.3.5.5 |
| ExplorEnz Enzyme Link: | ExplorEnz 6.3.5.5 |
| PRIAM enzyme-specific profiles Link: | PRIAM 6.3.5.5 |
| IntEnz Enzyme Link: | IntEnz 6.3.5.5 |
| MEDLINE Enzyme Link: | MEDLINE 6.3.5.5 |
| RHEA:18633 | 2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](=[*:3])-[NH2;+0:4].[*:5]=[C;H0;+0:6](-[OH;+0:7])-[OH;+0:8].[*:9]=[P;H0;+0:10](-[*:11])(-[*:12])-[O;H0;+0:13]-[*:14].[*:15]=[P;H0;+0:16](-[*:17])(-[*:18])-[O;H0;+0:19]-[*:20].[OH2;+0:21]>>[*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:7].[*:14]-[OH;+0:13].[*:20]-[OH;+0:19].[*:15]=[P;H0;+0:16](-[*:17])(-[*:18])-[O;H0;+0:8]-[C;H0;+0:6](=[*:5])-[NH2;+0:4].[*:9]=[P;H0;+0:10](-[*:11])(-[*:12])-[OH;+0:21] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Carbamoyl phosphate synthetase: a tunnel runs through it. | Holden HM, Thoden JB, Raushel FM | 1998 Dec | 9914247 |
| Carbamoyl phosphate synthetase: a crooked path from substrates to products. | Raushel FM, Thoden JB, Reinhart GD, Holden HM | 1998 Oct | 9818189 |
| Role of conserved residues within the carboxy phosphate domain of carbamoyl phosphate synthetase. | Stapleton MA, Javid-Majd F, Harmon MF, Hanks BA, Grahmann JL, Mullins LS, Raushel FM | 1996 Nov 12 | 8916922 |
| Glutamine-dependent carbamyl phosphate synthetase. Properties and distribution in normal and neoplastic rat tissues. | Yip MC, Knox WE | 1970 May 10 | 5442268 |
| Purification and properties of a bacterial carbamyl phosphate synthetase. | Kalman SM, Duffield PH, Brzozowski T | 1966 Apr 25 | 5329589 |
| Evidence for an activated form of carbon dioxide in the reaction catalyzed by Escherichia coli carbamyl phosphate synthetase. | Anderson PM, Meister A | 1965 Dec | 5326356 |
| Carbamoyl-phosphate synthetase. Creation of an escape route for ammonia. | Thoden JB, Huang X, Raushel FM, Holden HM | 2002 Oct 18 | 12130656 |
| The amidotransferase family of enzymes: molecular machines for the production and delivery of ammonia. | Raushel FM, Thoden JB, Holden HM | 1999 Jun 22 | 10387030 |